Description

Simple

An ingredient of products applied to the skin to help relieve muscle or joint pain.

Clinical

An ingredient of topical drugs for the relief of joint pain or muscle aches and pains.

Overview

A depressor amine derived by enzymatic decarboxylation of histidine. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter.

Pharmacology

Indication

Histamine phosphate is indicated as a diagnostic aid for evaluation of gastric acid secretory function.

Pharmacodynamic

Histamine stimulates gastric gland secretion, causing an increased secretion of gastric juice of high acidity. This action is probably due mainly to a direct action on parietal and chief gland cells.

Mechanism of action

Histamine acts directly on the blood vessels to dilate arteries and capillaries; this action is mediated by both H 1- and H 2-receptors. Capillary dilatation may produce flushing of the face, a decrease in systemic blood pressure, and gastric gland secretion, causing an increased secretion of gastri... Read more

Absorption

Readily absorbed after parenteral administration.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

LD50=807 mg/kg (mouse, oral). Side effects can lead to hypertension, hypotension, headache, dizziness, nervousness and tachycardia. Large overdoses can lead to seizures.

Adverse Effects

Contraindications

  • Regions: US
  • Patient Conditions:
      • Name: Steroid dependent asthmatics
      • Drugbank Id: DBCOND0108425
  • Regions: US
  • With Categories Coadmin:
      • Name: Adrenergic beta-Antagonists
      • Drugbank Id: DBCAT000456
      • Mesh Id: D000319
  • Regions: US
  • Patient Conditions:
      • Name: Unstable asthma
      • Drugbank Id: DBCOND0108424

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Histamine
Type a drug name in the box above to get started
  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
Acyclovir
The risk or severity of adverse effects can be increased when Acyclovir is combined with Histamine.
Agmatine
The serum concentration of Agmatine can be increased when it is combined with Histamine.
Amantadine
The serum concentration of Histamine can be increased when it is combined with Amantadine.
Amiloride
The serum concentration of Histamine can be increased when it is combined with Amiloride.
Aminohippuric acid
The serum concentration of Histamine can be increased when it is combined with Aminohippuric acid.
Amiodarone
The serum concentration of Amiodarone can be increased when it is combined with Histamine.
Apalutamide
The serum concentration of Histamine can be increased when it is combined with Apalutamide.
Baricitinib
The serum concentration of Histamine can be increased when it is combined with Baricitinib.
Bupropion
The excretion of Histamine can be decreased when combined with Bupropion.
Chlorpheniramine
The serum concentration of Histamine can be increased when it is combined with Chlorpheniramine.
Choline
The serum concentration of Histamine can be increased when it is combined with Choline.
Choline salicylate
The serum concentration of Choline salicylate can be increased when it is combined with Histamine.
Cimetidine
The serum concentration of Histamine can be increased when it is combined with Cimetidine.
Cisplatin
The serum concentration of Histamine can be increased when it is combined with Cisplatin.
Clopidogrel
The serum concentration of Histamine can be increased when it is combined with Clopidogrel.
Codeine
The risk or severity of adverse effects can be increased when Codeine is combined with Histamine.
Crizotinib
The serum concentration of Histamine can be increased when it is combined with Crizotinib.
D-Levofloxacin
The serum concentration of Histamine can be increased when it is combined with D-Levofloxacin.
Dacomitinib
The risk or severity of adverse effects can be increased when Dacomitinib is combined with Histamine.
Dalfampridine
The serum concentration of Dalfampridine can be increased when it is combined with Histamine.
1 References
  1. 1 . Middleton M, Sarno M, Agarwala SS, Glaspy J, Laurent A, McMasters K, Naredi P, O'Day S, Whitman E, Danson S, Cosford R, Gehlsen K: Pharmacokinetics of histamine dihydrochloride in healthy volunteers and cancer patients: implications for combined immunotherapy with interleukin-2. J Clin Pharmacol. 2002 Jul;42(7):774-81.PubMed: 12092744