Description

Simple

Clinical

Overview

Pharmacology

Indication

For the treatment of rheumatoid arthritis and type 2 diabetes.

Pharmacodynamic

Information currently not available.

Mechanism of action

Potential mechanisms of action for HE3286 include regulation of NF-kB and increasing the production of regulatory T cells (Treg cells). NF-kB is a well-known transcription factor that controls the production of inflammatory cytokines such as TNF-a and interferon-g. Treg cells are referred to in the... Read more

Absorption

Up to 25% oral bioavailability in mice.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
Cenobamate
The serum concentration of HE3286 can be decreased when it is combined with Cenobamate.
Haloperidol
The serum concentration of Haloperidol can be increased when it is combined with HE3286.
Metreleptin
The metabolism of HE3286 can be increased when combined with Metreleptin.
Pitolisant
The serum concentration of HE3286 can be decreased when it is combined with Pitolisant.
Ritonavir
The serum concentration of HE3286 can be increased when it is combined with Ritonavir.
1 References
  1. 1 . Auci D, Kaler L, Subramanian S, Huang Y, Frincke J, Reading C, Offner H: A new orally bioavailable synthetic androstene inhibits collagen-induced arthritis in the mouse: androstene hormones as regulators of regulatory T cells. Ann N Y Acad Sci. 2007 Sep;1110:630-40.PubMed: 17911478