Description

Simple

Clinical

Overview

Ramoplanin is a novel glycolipodepsipeptide antibiotic under development for the treatment of CDAD.

Pharmacology

Indication

For the treatment of bacterial infections.

Pharmacodynamic

Ramoplanin represents a new class of antibiotics with a novel mechanism of action that is highly effective against Staphylococci.

Mechanism of action

Ramoplanin is the first in a new class of antimicrobials to reach clinical trials. It is a glycolipodepsipeptide produced by the fermentation of Actinoplanes spp.. Ramoplanin blocks bacterial cell wall biosynthesis by interfering with peptidoglycan production. Ramoplanin inhibits the N-acetyl... Read more

Absorption

No/limited absorption.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The risk or severity of bleeding can be increased when Ramoplanin is combined with (R)-warfarin.
(S)-Warfarin
The risk or severity of bleeding can be increased when Ramoplanin is combined with (S)-Warfarin.
4-hydroxycoumarin
The risk or severity of bleeding can be increased when Ramoplanin is combined with 4-hydroxycoumarin.
Acenocoumarol
The risk or severity of bleeding can be increased when Ramoplanin is combined with Acenocoumarol.
BCG vaccine
The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Ramoplanin.
Clorindione
The risk or severity of bleeding can be increased when Ramoplanin is combined with Clorindione.
Coumarin
The risk or severity of bleeding can be increased when Ramoplanin is combined with Coumarin.
Dicoumarol
The risk or severity of bleeding can be increased when Ramoplanin is combined with Dicoumarol.
Diphenadione
The risk or severity of bleeding can be increased when Ramoplanin is combined with Diphenadione.
Ethyl biscoumacetate
The risk or severity of bleeding can be increased when Ramoplanin is combined with Ethyl biscoumacetate.
Fluindione
The risk or severity of bleeding can be increased when Ramoplanin is combined with Fluindione.
Lactulose
The therapeutic efficacy of Lactulose can be decreased when used in combination with Ramoplanin.
Phenindione
The risk or severity of bleeding can be increased when Ramoplanin is combined with Phenindione.
Phenprocoumon
The risk or severity of bleeding can be increased when Ramoplanin is combined with Phenprocoumon.
Picosulfuric acid
The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Ramoplanin.
Tioclomarol
The risk or severity of bleeding can be increased when Ramoplanin is combined with Tioclomarol.
Typhoid vaccine
The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Ramoplanin.
Warfarin
The risk or severity of bleeding can be increased when Ramoplanin is combined with Warfarin.
2 References
  1. 1 . Fang X, Tiyanont K, Zhang Y, Wanner J, Boger D, Walker S: The mechanism of action of ramoplanin and enduracidin. Mol Biosyst. 2006 Jan;2(1):69-76. Epub 2005 Nov 29.PubMed: 16880924
  2. 2 . Fulco P, Wenzel RP: Ramoplanin: a topical lipoglycodepsipeptide antibacterial agent. Expert Rev Anti Infect Ther. 2006 Dec;4(6):939-45.PubMed: 17181409