Description

Simple

Clinical

Overview

Camptothecin is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.

Pharmacology

Indication

Investigated for the treatment of cancer.

Pharmacodynamic

Camptothecin demonstrated strong anticancer activity in preliminary clinical trials but also low solubility and adverse drug reaction. Camptothecin is believed to be a potent topoisomerase inhibitor that interferes with the essential function of topoisomerase in DNA replication.

Mechanism of action

Camptothecin binds to the topoisomerase I and DNA complex resulting in a ternary complex, stabilizing it and preventing DNA re-ligation and therefore causes DNA damage which results in apoptosis.

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Acute oral toxicity (LD50) in mouse: 50.1 mg/kg

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
Abemaciclib
Abemaciclib may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Afatinib
Afatinib may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Alectinib
Alectinib may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Apalutamide
Apalutamide may increase the excretion rate of Camptothecin which could result in a lower serum level and potentially a reduction in efficacy.
Avatrombopag
Avatrombopag may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Baricitinib
Baricitinib may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Beclomethasone dipropionate
Beclomethasone dipropionate may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Brigatinib
Brigatinib may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Buprenorphine
Buprenorphine may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Cabazitaxel
Cabazitaxel may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Caffeine
Caffeine may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Cannabidiol
Cannabidiol may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Cholesterol
Cholesterol may increase the excretion rate of Camptothecin which could result in a lower serum level and potentially a reduction in efficacy.
Cobicistat
Cobicistat may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Cyclosporine
Cyclosporine may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Dabrafenib
Dabrafenib may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Daclatasvir
Daclatasvir may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Dacomitinib
Dacomitinib may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Daidzin
Daidzin may decrease the excretion rate of Camptothecin which could result in a higher serum level.
Darbepoetin alfa
The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Camptothecin.
2 References
  1. 1 . Wall ME, Wani MC: Camptothecin and taxol: from discovery to clinic. J Ethnopharmacol. 1996 Apr;51(1-3):239-53; discussion 253-4.PubMed: 9213622
  2. 2 . Kepler JA, Wani MC, McNaull JN, Wall ME, Levine SG: Plant antitumor agents. IV. An approach toward the synthesis of camptothecin. J Org Chem. 1969 Dec;34(12):3853-8.PubMed: 5357525