Description

Simple

Clinical

Overview

Geneticin (also known as G418) is an aminoglycoside antibiotic similar in structure to gentamicin B1, produced by Micromonospora rhodorangea. Geneticin blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells and is commonly used in laboratory research to select genetically engineered cells. Resistance to Geneticin is conferred by the neo gene from Tn5 encoding an aminoglycoside 3‘-phosphotransferase, APH 3‘ II.

Pharmacology

Indication

Information currently not available.

Pharmacodynamic

Information currently not available.

Mechanism of action

Information currently not available.

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The risk or severity of bleeding can be increased when Geneticin is combined with (R)-warfarin.
(S)-Warfarin
The risk or severity of bleeding can be increased when Geneticin is combined with (S)-Warfarin.
4-hydroxycoumarin
The risk or severity of bleeding can be increased when Geneticin is combined with 4-hydroxycoumarin.
Abacavir
Geneticin may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acarbose
Geneticin may decrease the excretion rate of Acarbose which could result in a higher serum level.
Aceclofenac
The risk or severity of nephrotoxicity can be increased when Aceclofenac is combined with Geneticin.
Acemetacin
The risk or severity of nephrotoxicity can be increased when Acemetacin is combined with Geneticin.
Acenocoumarol
The risk or severity of bleeding can be increased when Geneticin is combined with Acenocoumarol.
Acetaminophen
Geneticin may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Acetylcholine
The therapeutic efficacy of Acetylcholine can be decreased when used in combination with Geneticin.
Acetyldigitoxin
The risk or severity of adverse effects can be increased when Geneticin is combined with Acetyldigitoxin.
Acetyldigoxin
The risk or severity of adverse effects can be increased when Geneticin is combined with Acetyldigoxin.
Acetylsalicylic acid
The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Geneticin.
Aclidinium
Geneticin may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Geneticin may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir
Geneticin may decrease the excretion rate of Acyclovir which could result in a higher serum level.
Adefovir
The risk or severity of nephrotoxicity can be increased when Geneticin is combined with Adefovir.
Adefovir dipivoxil
The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Geneticin.
Albutrepenonacog alfa
Geneticin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Alclofenac
The risk or severity of nephrotoxicity can be increased when Alclofenac is combined with Geneticin.