Description

Simple

Clinical

Overview

An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines.

Additionally, genistein has antihelmintic activity. It has been determined to be the active ingredient in Felmingia vestita, which is a plant traditionally used against worms. It has shown to be effective in the treatment of common liver fluke, pork trematode and poultry cestode.

Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties. It has been investigated in clinical trials as an alternative to classical hormone therapy to help prevent cardiovascular disease in postmenopausal women [1].

Natural sources of genistein include tofu, fava beans, soybeans, kudzu, and lupin.

Pharmacology

Indication

Currently Genistein is being studied in clinical trials as a treatment for prostate cancer.

Pharmacodynamic

Information currently not available.

Mechanism of action

Genistein may inhibit cancer cell growth by blocking enzymes required for cell growth.

Genistein may decrease cardiovascular risk in postmenopausal women by interacting with the nuclear estrogen receptors to alter the transcription of cell specific genes. In randomized clinical trials, genistein... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Genistein
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The metabolism of (R)-warfarin can be increased when combined with Genistein.
(S)-Warfarin
The metabolism of (S)-Warfarin can be increased when combined with Genistein.
3,5-diiodothyropropionic acid
The therapeutic efficacy of 3,5-diiodothyropropionic acid can be decreased when used in combination with Genistein.
3,5-Diiodotyrosine
The therapeutic efficacy of 3,5-Diiodotyrosine can be decreased when used in combination with Genistein.
4-hydroxycoumarin
The metabolism of 4-hydroxycoumarin can be increased when combined with Genistein.
6-O-benzylguanine
The metabolism of 6-O-benzylguanine can be decreased when combined with Genistein.
8-azaguanine
The metabolism of 8-azaguanine can be decreased when combined with Genistein.
8-chlorotheophylline
The metabolism of 8-chlorotheophylline can be decreased when combined with Genistein.
9-aminocamptothecin
The metabolism of 9-aminocamptothecin can be increased when combined with Genistein.
9-Deazaguanine
The metabolism of 9-Deazaguanine can be decreased when combined with Genistein.
9-Methylguanine
The metabolism of 9-Methylguanine can be decreased when combined with Genistein.
Abaloparatide
The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Genistein.
Abatacept
The metabolism of Genistein can be increased when combined with Abatacept.
Abemaciclib
Genistein may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Abiraterone
The serum concentration of Genistein can be increased when it is combined with Abiraterone.
Acefylline
The metabolism of Acefylline can be decreased when combined with Genistein.
Acenocoumarol
The metabolism of Acenocoumarol can be increased when combined with Genistein.
Acetaminophen
The serum concentration of Acetaminophen can be increased when it is combined with Genistein.
Acetohexamide
The metabolism of Acetohexamide can be decreased when combined with Genistein.
Acetylsalicylic acid
The metabolism of Acetylsalicylic acid can be decreased when combined with Genistein.
2 References
  1. 1 . Crisafulli A, Altavilla D, Marini H, Bitto A, Cucinotta D, Frisina N, Corrado F, D'Anna R, Squadrito G, Adamo EB, Marini R, Romeo A, Cancellieri F, Buemi M, Squadrito F: Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women. Menopause. 2005 Mar;12(2):186-92.PubMed: 15772566
  2. 2 . Toner E, Brennan GP, Wells K, McGeown JG, Fairweather I: Physiological and morphological effects of genistein against the liver fluke, Fasciola hepatica. Parasitology. 2008 Sep;135(10):1189-203. doi: 10.1017/S0031182008004630.PubMed: 18771609