Description

Simple

Clinical

Overview

Aceprometazine is a is a drug with neuroleptic and anti-histamine properties. Although not widely prescribed, it is used in combination with meprobamate for the treatment of sleep disorders in France under the trade name Mepronizine.

Pharmacology

Indication

Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders.

Pharmacodynamic

Aceprometazine is a drug with neuroleptic and anti-histamine properties. It is not widely prescribed.

Mechanism of action

Aceprometazine, acting as an H1-receptor antagonist can induce sedation by being able to cross the blood-brain-barrier and binding to H1-receptors in the central nervous system.

Absorption

Rapidly absorbed following oral administration.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
2,5-Dimethoxy-4-ethylamphetamine
2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative and stimulatory activities of Aceprometazine.
2,5-Dimethoxy-4-ethylthioamphetamine
2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative and stimulatory activities of Aceprometazine.
4-Bromo-2,5-dimethoxyamphetamine
4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative and stimulatory activities of Aceprometazine.
4-Methoxyamphetamine
The risk or severity of adverse effects can be increased when 4-Methoxyamphetamine is combined with Aceprometazine.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of adverse effects can be increased when Aceprometazine is combined with 5-methoxy-N,N-dimethyltryptamine.
7-Nitroindazole
The risk or severity of adverse effects can be increased when Aceprometazine is combined with 7-Nitroindazole.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
The risk or severity of extrapyramidal symptoms can be increased when Aceprometazine is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Abexinostat
The risk or severity of QTc prolongation can be increased when Aceprometazine is combined with Abexinostat.
Acebutolol
The serum concentration of Acebutolol can be increased when it is combined with Aceprometazine.
Acepromazine
The risk or severity of adverse effects can be increased when Acepromazine is combined with Aceprometazine.
Acetazolamide
The risk or severity of adverse effects can be increased when Acetazolamide is combined with Aceprometazine.
Acetohexamide
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Aceprometazine.
Acetophenazine
The risk or severity of adverse effects can be increased when Acetophenazine is combined with Aceprometazine.
Acetyldigoxin
The risk or severity of QTc prolongation can be increased when Acetyldigoxin is combined with Aceprometazine.
Acetylglycinamide chloral hydrate
The risk or severity of adverse effects can be increased when Aceprometazine is combined with Acetylglycinamide chloral hydrate.
Aclidinium
Aceprometazine may increase the central nervous system depressant (CNS depressant) activities of Aclidinium.
Acrivastine
The risk or severity of QTc prolongation can be increased when Acrivastine is combined with Aceprometazine.
Adenosine
The risk or severity of QTc prolongation can be increased when Adenosine is combined with Aceprometazine.
Adinazolam
The risk or severity of adverse effects can be increased when Adinazolam is combined with Aceprometazine.
Adipiplon
The risk or severity of adverse effects can be increased when Aceprometazine is combined with Adipiplon.