Description

Simple

Clinical

Overview

Acepromazine is one of the phenothiazine derivative psychotropic drugs, used little in humans, however frequently in animals as a sedative and antiemetic.

Pharmacology

Indication

Acepromazine was first used in humans in the 1950s as an antipsychotic agent. It is now rarely used in humans. Acepromazine is frequently used in animals as a sedative and antiemetic. Its principal value is in quietening and calming anxious animals.

Pharmacodynamic

Acepromazine is one of the phenothiazine derivative psychotropic drugs. Acepromazine has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Acepromazine has strong antiadrenergic and weaker peripheral anticholinergic activity; ga... Read more

Mechanism of action

Acepromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive a... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

3 hours in horses.

Route of elimination

Information currently not available.

Toxicity

Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

  • Avoid alcohol.
  • Take with food. Food reduces irritation.

Interactions

Type in a drug name to check for interaction with Acepromazine
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The risk or severity of adverse effects can be increased when Acepromazine is combined with (R)-warfarin.
(S)-Warfarin
The risk or severity of adverse effects can be increased when Acepromazine is combined with (S)-Warfarin.
1-benzylimidazole
The risk or severity of hypertension can be increased when Acepromazine is combined with 1-benzylimidazole.
2,5-Dimethoxy-4-ethylamphetamine
The therapeutic efficacy of Acepromazine can be decreased when used in combination with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
The therapeutic efficacy of Acepromazine can be decreased when used in combination with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
The therapeutic efficacy of Acepromazine can be decreased when used in combination with 4-Bromo-2,5-dimethoxyamphetamine.
4-Bromo-2,5-dimethoxyphenethylamine
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Acepromazine.
4-hydroxycoumarin
The risk or severity of adverse effects can be increased when Acepromazine is combined with 4-hydroxycoumarin.
4-Methoxyamphetamine
The risk or severity of adverse effects can be increased when 4-Methoxyamphetamine is combined with Acepromazine.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of adverse effects can be increased when Acepromazine is combined with 5-methoxy-N,N-dimethyltryptamine.
7-Nitroindazole
The risk or severity of adverse effects can be increased when Acepromazine is combined with 7-Nitroindazole.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
The risk or severity of extrapyramidal symptoms can be increased when Acepromazine is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Abediterol
The therapeutic efficacy of Abediterol can be decreased when used in combination with Acepromazine.
Acebutolol
The serum concentration of Acebutolol can be increased when it is combined with Acepromazine.
Aceclofenac
The risk or severity of hypertension can be increased when Acepromazine is combined with Aceclofenac.
Acemetacin
The risk or severity of hypertension can be increased when Acepromazine is combined with Acemetacin.
Acenocoumarol
The risk or severity of adverse effects can be increased when Acepromazine is combined with Acenocoumarol.
Aceprometazine
The risk or severity of adverse effects can be increased when Acepromazine is combined with Aceprometazine.
Acetazolamide
The risk or severity of adverse effects can be increased when Acetazolamide is combined with Acepromazine.
Acetohexamide
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Acepromazine.