Description

Simple

Clinical

Overview

A 17-alkylated orally active androgenic steroid. A Schedule IV drug in Canada.

Pharmacology

Indication

An anabolic steroid which can theoretically aid in restauration and buildup of certain tissues, especially muscle. It is similar to synthetic testosterone and is still in early investigation. It was also investigated for use as a treatment for metastatic breast cancer.

Pharmacodynamic

Calusterone is a 17-alkylated orally active androgenic steroid. Calusterone may alter the metabolism of estradiol and reduce estrogen production. Calusterone has been investigated for possible antitumor properties.

Mechanism of action

The effects of calusterone in humans most likely occur by way of two main mechanisms: by activation of the androgen receptor, and by conversion to estradiol and activation of certain estrogen receptors.
Using testosterone as the prime example, free testosterone (T) is transported into the cytoplasm... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
Calusterone may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Calusterone may increase the anticoagulant activities of (S)-Warfarin.
4-hydroxycoumarin
Calusterone may increase the anticoagulant activities of 4-hydroxycoumarin.
Abciximab
Calusterone may increase the anticoagulant activities of Abciximab.
Acenocoumarol
Calusterone may increase the anticoagulant activities of Acenocoumarol.
Acetylsalicylic acid
Calusterone may increase the anticoagulant activities of Acetylsalicylic acid.
Aldosterone
The risk or severity of edema formation can be increased when Calusterone is combined with Aldosterone.
Alteplase
Calusterone may increase the anticoagulant activities of Alteplase.
Amediplase
Calusterone may increase the anticoagulant activities of Amediplase.
Anagrelide
Calusterone may increase the anticoagulant activities of Anagrelide.
Ancrod
Calusterone may increase the anticoagulant activities of Ancrod.
Anistreplase
Calusterone may increase the anticoagulant activities of Anistreplase.
Antithrombin Alfa
Calusterone may increase the anticoagulant activities of Antithrombin Alfa.
Antithrombin III human
Calusterone may increase the anticoagulant activities of Antithrombin III human.
Apixaban
Calusterone may increase the anticoagulant activities of Apixaban.
Ardeparin
Calusterone may increase the anticoagulant activities of Ardeparin.
Argatroban
Calusterone may increase the anticoagulant activities of Argatroban.
Astaxanthin
Calusterone may increase the anticoagulant activities of Astaxanthin.
Beclomethasone dipropionate
The risk or severity of edema formation can be increased when Calusterone is combined with Beclomethasone dipropionate.
Bemiparin
Calusterone may increase the anticoagulant activities of Bemiparin.
1 References
  1. 1 . Meli RJ, Ros PR: MR appearance of intra-abdominal metastatic melanoma. Magn Reson Imaging. 1992;10(4):705-8.PubMed: 1501542