Description

Simple

Clinical

Overview

Camazepam is a benzodiazepine which is a dimethyl carbamate ester of tamzepam, a metabolite of diazepam. Similarly to other drugs in its class, it has antxiolytic, anticonvulsant, hypnotic, and skeletal muscle relaxant properties. However, unlike other benzodiapeines camazepam is predominantly anxiolytic and is relatively weak as an anticonvulsant, hypnotic and skeletal muscle relaxant.

Camazepam also has less side effects, such as impaired cognition and reaction times, compared to other benzodiazepines. However, impairment of cognition and disrupted sleep patterns will occur at doses higher than 40mg of carazepam. Camazepam is also believed to increase attention, and is associated with skin disorders.

In the United States camazepam is regulated as a Schedule IV controlled substance.

Pharmacology

Indication

Camazepam has been used in placebo controlled studies for the treatment of patients suffering from anxiety and depression.

Pharmacodynamic

Information currently not available.

Mechanism of action

Camazepam has been shown to bind competitively to benzodiazepine receptors in the brain with a relatively low affinity in animal models. This binding of benzodiazepine receptors by camazepam and its active metabolites is responsible for its anticonvulsant effects. Notably, only three metabolites wer... Read more

Absorption

Almost completely absorbed into the bloodstream after oral administration. 90% bioavailability can be achieved in humans.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Renally eliminated.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
2,5-Dimethoxy-4-ethylthioamphetamine
The risk or severity of adverse effects can be increased when Camazepam is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
3-isobutyl-1-methyl-7H-xanthine
The therapeutic efficacy of Camazepam can be decreased when used in combination with 3-isobutyl-1-methyl-7H-xanthine.
4-Bromo-2,5-dimethoxyamphetamine
The risk or severity of adverse effects can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Camazepam.
4-Methoxyamphetamine
The risk or severity of adverse effects can be increased when 4-Methoxyamphetamine is combined with Camazepam.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of adverse effects can be increased when Camazepam is combined with 5-methoxy-N,N-dimethyltryptamine.
6-O-benzylguanine
The therapeutic efficacy of Camazepam can be decreased when used in combination with 6-O-benzylguanine.
7-Deazaguanine
The therapeutic efficacy of Camazepam can be decreased when used in combination with 7-Deazaguanine.
7-Nitroindazole
The risk or severity of adverse effects can be increased when Camazepam is combined with 7-Nitroindazole.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
The risk or severity of adverse effects can be increased when Camazepam is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
7,9-Dimethylguanine
The therapeutic efficacy of Camazepam can be decreased when used in combination with 7,9-Dimethylguanine.
8-azaguanine
The therapeutic efficacy of Camazepam can be decreased when used in combination with 8-azaguanine.
8-chlorotheophylline
The therapeutic efficacy of Camazepam can be decreased when used in combination with 8-chlorotheophylline.
9-Deazaguanine
The therapeutic efficacy of Camazepam can be decreased when used in combination with 9-Deazaguanine.
9-Methylguanine
The therapeutic efficacy of Camazepam can be decreased when used in combination with 9-Methylguanine.
Acefylline
The therapeutic efficacy of Camazepam can be decreased when used in combination with Acefylline.
Acepromazine
The risk or severity of adverse effects can be increased when Camazepam is combined with Acepromazine.
Aceprometazine
The risk or severity of adverse effects can be increased when Camazepam is combined with Aceprometazine.
Acetazolamide
The risk or severity of adverse effects can be increased when Acetazolamide is combined with Camazepam.
Acetophenazine
The risk or severity of adverse effects can be increased when Acetophenazine is combined with Camazepam.
Acetylglycinamide chloral hydrate
The risk or severity of adverse effects can be increased when Camazepam is combined with Acetylglycinamide chloral hydrate.
3 References
  1. 1 . Lu XL, Yang SK: Enantiomer resolution of camazepam and its derivatives and enantioselective metabolism of camazepam by human liver microsomes. J Chromatogr A. 1994 Apr 22;666(1-2):249-57.PubMed: 7911374
  2. 2 . Morino A, Sasaki H, Mukai H, Sugiyama M: Receptor-mediated model relating anticonvulsant effect to brain levels of camazepam in the presence of its active metabolites. J Pharmacokinet Biopharm. 1986 Jun;14(3):309-21.PubMed: 2878071
  3. 3 . Morino A, Sugiyama M: Relation between time courses of pharmacological effects and of plasma levels of camazepam and its active metabolites in rats. J Pharmacobiodyn. 1985 Aug;8(8):597-606.PubMed: 2868088