Description

Simple

A medication used to reduce pain in muscles.

Clinical

An NSAID analgesic used in the symptomatic relief of mild to moderate muscular pain.

Overview

Magnesium salicylate is a non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain. It is available in several over-the-counter (OTC) formulations. Though the recommended doseage is 1160 mg every six hours, per package directions of the Doan's OTC brand (580 mg magnesium salicylate tetrahydrate, equivalent to 934.4 mg anhydrous magnesium salicylate), effective pain relief is often found with a half dosage, with reduced anti-inflammatory results.

Pharmacology

Indication

Magnesium salicylate is a common analgesic and non-steroidal anti-inflammatory drug (NSAID) used to treat mild to moderate muscular pain

Pharmacodynamic

Information currently not available.

Mechanism of action

Most NSAIDs act as nonselective inhibitors of the enzyme cyclooxygenase (COX), inhibiting both the cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) isoenzymes. COX catalyzes the formation of prostaglandins and thromboxane from arachidonic acid (itself derived from the cellular phospholipid bila... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The risk or severity of bleeding and hemorrhage can be increased when Magnesium salicylate is combined with (R)-warfarin.
(S)-Warfarin
The risk or severity of bleeding and hemorrhage can be increased when Magnesium salicylate is combined with (S)-Warfarin.
1-benzylimidazole
The risk or severity of hypertension can be increased when Magnesium salicylate is combined with 1-benzylimidazole.
1alpha-Hydroxyvitamin D5
The serum concentration of Magnesium salicylate can be increased when it is combined with 1alpha-Hydroxyvitamin D5.
1alpha,24S-Dihydroxyvitamin D2
The serum concentration of Magnesium salicylate can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2.
2,5-Dimethoxy-4-ethylamphetamine
The risk or severity of hypertension can be increased when Magnesium salicylate is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
The risk or severity of hypertension can be increased when Magnesium salicylate is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Magnesium salicylate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
4-Bromo-2,5-dimethoxyamphetamine
The risk or severity of hypertension can be increased when Magnesium salicylate is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-hydroxycoumarin
The risk or severity of bleeding and hemorrhage can be increased when Magnesium salicylate is combined with 4-hydroxycoumarin.
4-Methoxyamphetamine
The risk or severity of hypertension can be increased when Magnesium salicylate is combined with 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of hypertension can be increased when Magnesium salicylate is combined with 5-methoxy-N,N-dimethyltryptamine.
Abacavir
Magnesium salicylate may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abciximab
The risk or severity of bleeding and hemorrhage can be increased when Magnesium salicylate is combined with Abciximab.
Abediterol
The risk or severity of hypertension can be increased when Magnesium salicylate is combined with Abediterol.
Acarbose
Magnesium salicylate may decrease the excretion rate of Acarbose which could result in a higher serum level.
Acebutolol
Magnesium salicylate may decrease the antihypertensive activities of Acebutolol.
Aceclofenac
The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Aceclofenac.
Acemetacin
The risk or severity of adverse effects can be increased when Magnesium salicylate is combined with Acemetacin.
Acenocoumarol
The risk or severity of bleeding and hemorrhage can be increased when Magnesium salicylate is combined with Acenocoumarol.