Description

Simple

A medication or mineral used as a health supplement and antacid for heartburn or upset stomach.

Clinical

A compound commonly used as a laxative for the symptomatic relief of acid indigestion and upset stomach, and in health supplements for cardiovascular and neuromuscular health.

Overview

Magnesium oxide is an inorganic compound that occurs in nature as the mineral periclase. In aqueous media combines quickly with water to form magnesium hydroxide. It is used as an antacid and mild laxative and has many nonmedicinal uses.

Pharmacology

Indication

Indicated for over-the-counter use as a supplement for cardiovascular and neuromuscular health, and as an antacid for relief of acid indigestion and upset stomach.

Pharmacodynamic

Information currently not available.

Mechanism of action

The term "Milk of Magnesia" was first used to describe a white aqueous, mildly alkaline suspension of magnesium hydroxide formulated at about 8%w/v. Milk of magnesia is primarily used to alleviate constipation, but can also be used to relieve indigestion and heartburn. When taken internally by mouth... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
1alpha-Hydroxyvitamin D5
The serum concentration of Magnesium oxide can be increased when it is combined with 1alpha-Hydroxyvitamin D5.
1alpha,24S-Dihydroxyvitamin D2
The serum concentration of Magnesium oxide can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2.
2,5-Dimethoxy-4-ethylamphetamine
The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be increased when it is combined with Magnesium oxide.
2,5-Dimethoxy-4-ethylthioamphetamine
The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be increased when it is combined with Magnesium oxide.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Magnesium oxide can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
4-Bromo-2,5-dimethoxyamphetamine
The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be increased when it is combined with Magnesium oxide.
Abafungin
Magnesium oxide can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acepromazine
Magnesium oxide can cause a decrease in the absorption of Acepromazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Aceprometazine
Magnesium oxide can cause a decrease in the absorption of Aceprometazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetaminophen
Magnesium oxide can cause a decrease in the absorption of Acetaminophen resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetazolamide
The risk or severity of adverse effects can be increased when Acetazolamide is combined with Magnesium oxide.
Acetophenazine
Magnesium oxide can cause a decrease in the absorption of Acetophenazine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Acetyldigoxin
The serum concentration of Acetyldigoxin can be decreased when it is combined with Magnesium oxide.
Aclidinium
The therapeutic efficacy of Magnesium oxide can be decreased when used in combination with Aclidinium.
Agmatine
The risk or severity of hypotension can be increased when Agmatine is combined with Magnesium oxide.
Albaconazole
Magnesium oxide can cause a decrease in the absorption of Albaconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Alcuronium
The therapeutic efficacy of Alcuronium can be increased when used in combination with Magnesium oxide.
Aldosterone
The bioavailability of Aldosterone can be decreased when combined with Magnesium oxide.
Alendronic acid
The serum concentration of Alendronic acid can be decreased when it is combined with Magnesium oxide.
Alfacalcidol
The serum concentration of Magnesium oxide can be increased when it is combined with Alfacalcidol.
2 References
  1. 1 . Kh R, Khullar M, Kashyap M, Pandhi P, Uppal R: Effect of oral magnesium supplementation on blood pressure, platelet aggregation and calcium handling in deoxycorticosterone acetate induced hypertension in rats. J Hypertens. 2000 Jul;18(7):919-26.PubMed: 10930190
  2. 2 . Shechter M, Merz CN, Paul-Labrador M, Meisel SR, Rude RK, Molloy MD, Dwyer JH, Shah PK, Kaul S: Oral magnesium supplementation inhibits platelet-dependent thrombosis in patients with coronary artery disease. Am J Cardiol. 1999 Jul 15;84(2):152-6.PubMed: 10426331