Description

Simple

Clinical

Overview

A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.

Pharmacology

Indication

For the treatment of bacterial infections.

Pharmacodynamic

Josamycin is a macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.

Mechanism of action

The mechanism of action of macrolides such as Josamycin is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl tRNA. This action is mainly bacteriostatic, but can also be bactericidal in hig... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Josamycin
Type a drug name in the box above to get started
  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The serum concentration of (R)-warfarin can be increased when it is combined with Josamycin.
(S)-Warfarin
The serum concentration of (S)-Warfarin can be increased when it is combined with Josamycin.
3-isobutyl-1-methyl-7H-xanthine
The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Josamycin.
4-hydroxycoumarin
The serum concentration of 4-hydroxycoumarin can be increased when it is combined with Josamycin.
6-O-benzylguanine
The metabolism of 6-O-benzylguanine can be decreased when combined with Josamycin.
7-Deazaguanine
The metabolism of 7-Deazaguanine can be decreased when combined with Josamycin.
7,9-Dimethylguanine
The metabolism of 7,9-Dimethylguanine can be decreased when combined with Josamycin.
8-azaguanine
The metabolism of 8-azaguanine can be decreased when combined with Josamycin.
8-chlorotheophylline
The metabolism of 8-chlorotheophylline can be decreased when combined with Josamycin.
9-Deazaguanine
The metabolism of 9-Deazaguanine can be decreased when combined with Josamycin.
9-Methylguanine
The metabolism of 9-Methylguanine can be decreased when combined with Josamycin.
Acefylline
The metabolism of Acefylline can be decreased when combined with Josamycin.
Acenocoumarol
The serum concentration of Acenocoumarol can be increased when it is combined with Josamycin.
Acetyldigitoxin
The serum concentration of Acetyldigitoxin can be increased when it is combined with Josamycin.
Acetyldigoxin
The serum concentration of Acetyldigoxin can be increased when it is combined with Josamycin.
Aldosterone
The serum concentration of Aldosterone can be increased when it is combined with Josamycin.
Alfentanil
The serum concentration of Alfentanil can be increased when it is combined with Josamycin.
Alprazolam
The serum concentration of Alprazolam can be increased when it is combined with Josamycin.
Aminophylline
The metabolism of Aminophylline can be decreased when combined with Josamycin.
Atorvastatin
The risk or severity of adverse effects can be increased when Josamycin is combined with Atorvastatin.
1 References
  1. 1 . Przybylski P, Pyta K, Stefanska J, Brzezinski B, Bartl F: Structure elucidation, complete NMR assignment and PM5 theoretical studies of new hydroxy-aminoalkyl-alpha,beta-unsaturated derivatives of the macrolide antibiotic josamycin. Magn Reson Chem. 2010 Apr;48(4):286-96. doi: 10.1002/mrc.2574.PubMed: 20186698