Description

Simple

A medication used to stop excessive bleeding after childbirth in women.

Clinical

An oxytocin agent used to control postpartum hemorrhage and bleeding after giving birth.

Overview

Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin -- it causes contraction of the uterus.

Pharmacology

Indication

Used to control postpartum hemorrhage and bleeding after giving birth.

Pharmacodynamic

Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is sold under the trade name Duratocin. It is an analogue of oxytocin, and its action is similar to that of oxytocin; it causes contraction of the uterus.

Mechanism of action

Carbetocin binds to oxytocin receptors present on the smooth musculature of the uterus, resulting in rhythmic contractions of the uterus, increased frequency of existing contractions, and increased uterine tone. The oxytocin receptor content of the uterus is very low in the non-pregnant state, and i... Read more

Absorption

Bioavailability is 80% following intramuscular injection.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

40 minutes

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

  • Regions: Canada
  • Patient Conditions:
      • Name: Prior to delivery
      • Drugbank Id: DBCOND0108312
  • Regions: Canada
  • Patient Conditions:
      • Name: Serious cardiovascular disorders
      • Drugbank Id: DBCOND0108313
  • Hypersensitivity:
    • oxytocin
  • Regions: Canada
  • Regions: Canada
  • Age Groups:
    • children

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Carbetocin
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the orthostatic hypotensive activities of Carbetocin.
Acebutolol
The therapeutic efficacy of Acebutolol can be increased when used in combination with Carbetocin.
Aldesleukin
The risk or severity of adverse effects can be increased when Aldesleukin is combined with Carbetocin.
Aliskiren
The therapeutic efficacy of Aliskiren can be increased when used in combination with Carbetocin.
Alprenolol
The therapeutic efficacy of Alprenolol can be increased when used in combination with Carbetocin.
Ambrisentan
The therapeutic efficacy of Ambrisentan can be increased when used in combination with Carbetocin.
Amifostine
The risk or severity of adverse effects can be increased when Amifostine is combined with Carbetocin.
Amiloride
The risk or severity of adverse effects can be increased when Amiloride is combined with Carbetocin.
Amiodarone
The risk or severity of adverse effects can be increased when Amiodarone is combined with Carbetocin.
Amlodipine
The therapeutic efficacy of Amlodipine can be increased when used in combination with Carbetocin.
Amobarbital
Amobarbital may increase the hypotensive activities of Carbetocin.
Amphetamine
Amphetamine may increase the orthostatic hypotensive activities of Carbetocin.
Amphotericin B
The risk or severity of adverse effects can be increased when Amphotericin B is combined with Carbetocin.
Amyl Nitrite
The risk or severity of adverse effects can be increased when Carbetocin is combined with Amyl Nitrite.
Angiotensin 1-7
The therapeutic efficacy of Angiotensin 1-7 can be increased when used in combination with Carbetocin.
Apomorphine
The risk or severity of adverse effects can be increased when Apomorphine is combined with Carbetocin.
Aripiprazole
Aripiprazole may increase the hypotensive activities of Carbetocin.
Aripiprazole lauroxil
Aripiprazole lauroxil may increase the hypotensive activities of Carbetocin.
Arotinolol
The risk or severity of adverse effects can be increased when Carbetocin is combined with Arotinolol.
Arsenic trioxide
The risk or severity of adverse effects can be increased when Arsenic trioxide is combined with Carbetocin.