Description

Simple

A medication used for anesthesia to stop pain during medical procedures or surgeries.

Clinical

A general inhalation anesthetic used for the induction and maintenance of general anesthesia.

Overview

A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)

Pharmacology

Indication

For the induction and maintenance of general anesthesia

Pharmacodynamic

Halothane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does... Read more

Mechanism of action

Halothane causes general anaethesia due to its actions on multiple ion channels, which ultimately depresses nerve conduction, breathing, cardiac contractility. Its immobilizing effects have been attributed to its binding to potassium channels in cholinergic neurons. Halothane's effect are also likel... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Toxic effects of halothane include malignant hyperthermia and hepatitis.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The metabolism of (R)-warfarin can be decreased when combined with Halothane.
(S)-Warfarin
The metabolism of (S)-Warfarin can be decreased when combined with Halothane.
1-benzylimidazole
The risk or severity of hypertension can be increased when Halothane is combined with 1-benzylimidazole.
2,5-Dimethoxy-4-ethylamphetamine
The risk or severity of hypertension can be increased when Halothane is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
The risk or severity of adverse effects can be increased when Halothane is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
The risk or severity of adverse effects can be increased when Halothane is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-Methoxyamphetamine
The risk or severity of adverse effects can be increased when Halothane is combined with 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of adverse effects can be increased when Halothane is combined with 5-methoxy-N,N-dimethyltryptamine.
7-Nitroindazole
The risk or severity of adverse effects can be increased when Halothane is combined with 7-Nitroindazole.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the orthostatic hypotensive activities of Halothane.
Abatacept
The metabolism of Halothane can be increased when combined with Abatacept.
Abediterol
The risk or severity of hypertension can be increased when Halothane is combined with Abediterol.
Abiraterone
The metabolism of Halothane can be decreased when combined with Abiraterone.
Acebutolol
The therapeutic efficacy of Acebutolol can be increased when used in combination with Halothane.
Aceclofenac
The risk or severity of hypertension can be increased when Halothane is combined with Aceclofenac.
Acemetacin
The risk or severity of hypertension can be increased when Halothane is combined with Acemetacin.
Acenocoumarol
The metabolism of Acenocoumarol can be decreased when combined with Halothane.
Acepromazine
The risk or severity of adverse effects can be increased when Halothane is combined with Acepromazine.
Aceprometazine
The risk or severity of adverse effects can be increased when Halothane is combined with Aceprometazine.
Acetaminophen
Halothane may increase the hepatotoxic activities of Acetaminophen.
1 References
  1. 1 . Bovill JG: Inhalation anaesthesia: from diethyl ether to xenon. Handb Exp Pharmacol. 2008;(182):121-42. doi: 10.1007/978-3-540-74806-9_6.PubMed: 18175089