Description

Simple

Clinical

Overview

Candicidin is an antibiotic obtained from a streptomyces (Streptomyces griseus) and active against some fungi of the genus Candida (C. albicans). Candicidin is administered intravaginally in the treatment of vulvovaginal candidiasis.

Pharmacology

Indication

Used in the topical treatment of vulvovaginal candidiasis.

Pharmacodynamic

Candicidin is a polyene antifungal antibiotic produced by a strain of Streptomyces griseus. It is especially effective against Candida albicans (more effective than amphotericin B), and is administered intravaginally in the treatment of vulvovaginal candidiasis.

Mechanism of action

Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of Candicidin. Candicidin binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. There is some evidence that the binding site in the cell wall may be... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The serum concentration of (R)-warfarin can be increased when it is combined with Candicidin.
(S)-Warfarin
The serum concentration of (S)-Warfarin can be increased when it is combined with Candicidin.
3-isobutyl-1-methyl-7H-xanthine
The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Candicidin.
4-hydroxycoumarin
The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Candicidin.
6-O-benzylguanine
The metabolism of 6-O-benzylguanine can be decreased when combined with Candicidin.
7-Deazaguanine
The metabolism of 7-Deazaguanine can be decreased when combined with Candicidin.
7,9-Dimethylguanine
The metabolism of 7,9-Dimethylguanine can be decreased when combined with Candicidin.
8-azaguanine
The metabolism of 8-azaguanine can be decreased when combined with Candicidin.
8-chlorotheophylline
The metabolism of 8-chlorotheophylline can be decreased when combined with Candicidin.
9-aminocamptothecin
The metabolism of 9-aminocamptothecin can be decreased when combined with Candicidin.
9-Deazaguanine
The metabolism of 9-Deazaguanine can be decreased when combined with Candicidin.
9-Methylguanine
The metabolism of 9-Methylguanine can be decreased when combined with Candicidin.
Acefylline
The metabolism of Acefylline can be decreased when combined with Candicidin.
Acenocoumarol
The serum concentration of Acenocoumarol can be increased when it is combined with Candicidin.
Acetyldigitoxin
The serum concentration of Acetyldigitoxin can be increased when it is combined with Candicidin.
Acetyldigoxin
The serum concentration of Acetyldigoxin can be increased when it is combined with Candicidin.
Albendazole
The metabolism of Albendazole can be decreased when combined with Candicidin.
Aldosterone
The serum concentration of Aldosterone can be increased when it is combined with Candicidin.
Alfentanil
The serum concentration of Alfentanil can be increased when it is combined with Candicidin.
Alfuzosin
The metabolism of Alfuzosin can be decreased when combined with Candicidin.