Description

Simple

An antibiotic used to treat bacterial infections in various locations of the body, including the respiratory tract, and skin.

Clinical

A cephalosporin antibiotic used in the treatment of various bacterial infections, such as pharyngitis, tonsillitis, otitis media, and uncomplicated skin infections.

Overview

Cefprozil is a cephalosporin antibiotic that is commonly employed to treat a variety of bacterial infections, including those of the ear and skin, bronchitis, and others.

Pharmacology

Indication

For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph

Pharmacodynamic

Cefprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections, and respiratory tract infections.

Mechanism of action

Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes... Read more

Absorption

Oral bioavailability is approximately 95%.

Protein binding

36%

Volume of distribution

0.23 L/kg

Clearance

3 mL/min/kg [fasting subjects]

Half life

1.3 hours

Route of elimination

Information currently not available.

Toxicity

Single 5000 mg/kg oral doses of cefprozil caused no mortality or signs of toxicity in adult, weaning or neonatal rats, or adult mice. A single oral dose of 3000 mg/kg caused diarrhea and loss of appetite in cynomolgus monkeys, but no mortality.

Adverse Effects

Contraindications

  • Hypersensitivity:
    • cephalosporins
  • Regions: US

Food Interactions

  • Take with or without food. The absorption is unaffected by food.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The risk or severity of bleeding can be increased when Cefprozil is combined with (R)-warfarin.
(S)-Warfarin
The risk or severity of bleeding can be increased when Cefprozil is combined with (S)-Warfarin.
4-hydroxycoumarin
The risk or severity of bleeding can be increased when Cefprozil is combined with 4-hydroxycoumarin.
Abacavir
Cefprozil may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abciximab
The therapeutic efficacy of Abciximab can be decreased when used in combination with Cefprozil.
Acarbose
Cefprozil may decrease the excretion rate of Acarbose which could result in a higher serum level.
Aceclofenac
Cefprozil may decrease the excretion rate of Aceclofenac which could result in a higher serum level.
Acemetacin
The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Acemetacin.
Acenocoumarol
The risk or severity of bleeding can be increased when Cefprozil is combined with Acenocoumarol.
Acetaminophen
Cefprozil may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Acetylsalicylic acid
The risk or severity of nephrotoxicity can be increased when Acetylsalicylic acid is combined with Cefprozil.
Aclidinium
Cefprozil may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Cefprozil may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir
Cefprozil may decrease the excretion rate of Acyclovir which could result in a higher serum level.
Adefovir
The risk or severity of nephrotoxicity can be increased when Cefprozil is combined with Adefovir.
Adefovir dipivoxil
The risk or severity of nephrotoxicity can be increased when Adefovir dipivoxil is combined with Cefprozil.
Albutrepenonacog alfa
Cefprozil may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Alclofenac
Cefprozil may decrease the excretion rate of Alclofenac which could result in a higher serum level.
Aldesleukin
Cefprozil may decrease the excretion rate of Aldesleukin which could result in a higher serum level.
Alendronic acid
The risk or severity of nephrotoxicity and hypocalcemia can be increased when Cefprozil is combined with Alendronic acid.