Description

Simple

A medication used to treat acid reflux and to help heal stomach ulcers.

Clinical

A proton pump inhibitor used to help gastrointestinal ulcers heal, to treat symptoms of gastroesophageal reflux disease (GERD), to eradicate Helicobacter pylori, and to treat hypersecretory conditions such as Zollinger-Ellison Syndrome.

Overview

Rabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.

Pharmacology

Indication

For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, H. pylori eradication, and prevention of gastroinetestinal bleeds with NSAID use.

Pharmacodynamic

Rabeprazole prevents the production of acid in the stomach. It reduces symptoms and prevents injury to the esophagus or stomach in patients with gastroesophageal reflux disease (GERD) or ulcers. Rabeprazole is also useful in conditions that produce too much stomach acid such as Zollinger-Ellison syn... Read more

Mechanism of action

Rabeprazole belongs to a class of antisecretory compounds (substituted benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2-receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H+/K+ATPase (hydrogen-p... Read more

Absorption

Absolute bioavailability is approximately 52%.

Protein binding

96.3% (bound to human plasma proteins)

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

1-2 hours (in plasma)

Route of elimination

Following a single 20 mg oral dose of 14C-labeled rabeprazole, approximately 90% of the drug was eliminated in the urine, primarily as thioether carboxylic acid; its glucuronide, and mercapturic acid metabolites.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

  • Regions: US
  • With Drugs Coadmin:
      • Name: Rilpivirine
      • Drugbank Id: DB08864

Food Interactions

  • Take with or without food. Food delays drug absorption, but not to a clinically significant extent.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The serum concentration of (R)-warfarin can be increased when it is combined with Rabeprazole.
(S)-Warfarin
The serum concentration of (S)-Warfarin can be increased when it is combined with Rabeprazole.
4-hydroxycoumarin
The metabolism of 4-hydroxycoumarin can be decreased when combined with Rabeprazole.
4-Methoxyamphetamine
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Rabeprazole.
5-methoxy-N,N-dimethyltryptamine
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Rabeprazole.
6-O-benzylguanine
The metabolism of 6-O-benzylguanine can be increased when combined with Rabeprazole.
8-azaguanine
The metabolism of 8-azaguanine can be increased when combined with Rabeprazole.
8-chlorotheophylline
The metabolism of 8-chlorotheophylline can be increased when combined with Rabeprazole.
9-aminocamptothecin
The metabolism of 9-aminocamptothecin can be decreased when combined with Rabeprazole.
9-Deazaguanine
The metabolism of 9-Deazaguanine can be increased when combined with Rabeprazole.
9-Methylguanine
The metabolism of 9-Methylguanine can be increased when combined with Rabeprazole.
Abacavir
Abacavir may decrease the excretion rate of Rabeprazole which could result in a higher serum level.
Abatacept
The metabolism of Rabeprazole can be increased when combined with Abatacept.
Abemaciclib
Rabeprazole may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Abiraterone
The metabolism of Abiraterone can be decreased when combined with Rabeprazole.
Acarbose
Acarbose may decrease the excretion rate of Rabeprazole which could result in a higher serum level.
Acebutolol
The metabolism of Acebutolol can be decreased when combined with Rabeprazole.
Aceclofenac
Aceclofenac may decrease the excretion rate of Rabeprazole which could result in a higher serum level.
Acefylline
The metabolism of Acefylline can be increased when combined with Rabeprazole.
Acemetacin
Acemetacin may decrease the excretion rate of Rabeprazole which could result in a higher serum level.