Description

Simple

Clinical

Overview

Hesperetin belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside [hesperidin], is the predominant flavonoid in lemons and oranges.

Pharmacology

Indication

For lowering cholesterol and, possibly, otherwise favorably affecting lipids. In vitro research also suggests the possibility that hesperetin might have some anticancer effects and that it might have some anti-aromatase activity, as well as activity again.

Pharmacodynamic

Hesperetin is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. Hesperetin may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic, vasoprotective and anticarcinogenic actions.

Mechanism of action

Hesperetin reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly an... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The metabolism of (R)-warfarin can be decreased when combined with Hesperetin.
6-O-benzylguanine
The metabolism of 6-O-benzylguanine can be decreased when combined with Hesperetin.
8-azaguanine
The metabolism of 8-azaguanine can be decreased when combined with Hesperetin.
8-chlorotheophylline
The metabolism of 8-chlorotheophylline can be decreased when combined with Hesperetin.
9-Deazaguanine
The metabolism of 9-Deazaguanine can be decreased when combined with Hesperetin.
9-Methylguanine
The metabolism of 9-Methylguanine can be decreased when combined with Hesperetin.
Abatacept
The metabolism of Hesperetin can be increased when combined with Abatacept.
Abemaciclib
Hesperetin may decrease the excretion rate of Abemaciclib which could result in a higher serum level.
Abiraterone
The serum concentration of Hesperetin can be increased when it is combined with Abiraterone.
Acefylline
The metabolism of Acefylline can be decreased when combined with Hesperetin.
Acenocoumarol
The metabolism of Acenocoumarol can be decreased when combined with Hesperetin.
Acetaminophen
The metabolism of Hesperetin can be decreased when combined with Acetaminophen.
Acyclovir
The metabolism of Hesperetin can be decreased when combined with Acyclovir.
Adalimumab
The metabolism of Hesperetin can be increased when combined with Adalimumab.
Afatinib
Hesperetin may decrease the excretion rate of Afatinib which could result in a higher serum level.
Afelimomab
The metabolism of Hesperetin can be increased when combined with Afelimomab.
Agomelatine
The metabolism of Agomelatine can be decreased when combined with Hesperetin.
Albendazole
The metabolism of Hesperetin can be decreased when combined with Albendazole.
Albinterferon Alfa-2B
The metabolism of Hesperetin can be decreased when combined with Albinterferon Alfa-2B.
Allopurinol
Hesperetin may decrease the excretion rate of Allopurinol which could result in a higher serum level.