A medication used to lower the amount of cholesterol in the blood and decrease the chance of having a heart attack or stroke.


An HMG-CoA reductase inhibitor used to lower lipid levels and reduce the risk of cardiovascular disease including myocardial infarction and stroke.


Atorvastatin (Lipitor®), is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease. More specifically, statin medications competitively inhibit the enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) Reductase,[8] which catalyzes the conversion of HMG-CoA to mevalonic acid. This conversion is a critical metabolic reaction involved in the production of several compounds involved in lipid metabolism and transport, including cholesterol, low-density lipoprotein (LDL) (sometimes referred to as "bad cholesterol"), and very-low-density lipoprotein (VLDL). Prescribing statins is considered standard practice for patients following any cardiovascular event, and for people who are at moderate to high risk of developing cardiovascular disease. The evidence supporting statin use, coupled with minimal side effects and long term benefits, has resulted in wide use of this medication in North America.[Read more



Atorvastatin is indicated for the treatment of several types of dyslipidemias, including primary hyperlipidemia and mixed dyslipidemia in adults, hypertriglyceridemia, primary dysbetalipoproteinemia, homozygous familial hypercholesterolemia, and heterozygous familial hypercholesterolemia in adolesce... Read more


Atorvastatin is an oral antilipemic agent that reversibly inhibits HMG-CoA reductase. It lowers total cholesterol, low-density lipoprotein-cholesterol (LDL-C), apolipoprotein B (apo B), non-high density lipoprotein-cholesterol (non-HDL-C), and triglyceride (TG) plasma concentrations while increasing... Read more

Mechanism of action

Atorvastatin is a statin medication and a competitive inhibitor of the enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol biosynthesis.[ Read more


Atorvastatin presents a dose-dependent and non-linear pharmacokinetic profile.[4] It is very rapidly absorbed after oral admin... Read more

Protein binding

Atorvastatin is highly bound to plasma proteins and over 98% of the administered dose is found in a bound form.[39,40 Read more

Volume of distribution

The reported volume of distribution of atorvastatin is of 380 L.[39,40]


The registered total plasma clearance of atorvastatin is of 625 ml/min.[5]

Half life

The half-life of atorvastatin is 14 hours while the half-life of its metabolites can reach up to 30 hours.[39,40]

Route of elimination

Atorvastatin and its metabolites are mainly eliminated in the bile without enterohepatic recirculation. The renal elimination of atorvastatin is very minimal and represents less than 1% of the eliminated dose.[39, Read more


The reported LD50 of oral atorvastatin in mice is higher than 5000 mg/kg.[MSDS] In cases of overdose with atorvastatin, there is reported symptoms of complicated breathing, jaundice, liver damage, dark urine, muscle pain, and seizures.[ Read more

Adverse Effects


  • Route:
    • Oral
  • Dose Form:
    • Tablet
  • Hypersensitivity:
    • true
  • Regions: US
  • Regions: US
  • Patient Conditions:
      • Name: Nursing mothers
      • Drugbank Id: DBCOND0107390
  • Regions: US
  • Patient Conditions:
      • Name: Pregnancy
      • Drugbank Id: DBCOND0018394
  • Regions: US
  • Patient Conditions:
      • Name: Active liver disease
      • Drugbank Id: DBCOND0107507
      • Modification Of:
        • Condition Status: active
        • Base:
          • Name: Liver Disease
          • Drugbank Id: DBCOND0028338

Food Interactions

  • Avoid grapefruit products. Grapefruit products may increase the risk for atorvastatin related adverse effects such as myopathy and rhabdomyolysis.
  • Take with or without food. Food decreases absorption but not to a clinically significant extent.


Type in a drug name to check for interaction with Atorvastatin
Type a drug name in the box above to get started
  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
The risk or severity of bleeding can be increased when Atorvastatin is combined with (R)-warfarin.
The risk or severity of bleeding can be increased when Atorvastatin is combined with (S)-Warfarin.
The risk or severity of bleeding can be increased when Atorvastatin is combined with 4-hydroxycoumarin.
6-Deoxyerythronolide B
The risk or severity of adverse effects can be increased when 6-Deoxyerythronolide B is combined with Atorvastatin.
The metabolism of Atorvastatin can be decreased when combined with 7-ethyl-10-hydroxycamptothecin.
The risk or severity of myopathy can be increased when Abafungin is combined with Atorvastatin.
The metabolism of Atorvastatin can be increased when combined with Abatacept.
The metabolism of Atorvastatin can be decreased when combined with Abiraterone.
The metabolism of Atorvastatin can be decreased when combined with Acalabrutinib.
The risk or severity of bleeding can be increased when Atorvastatin is combined with Acenocoumarol.
The metabolism of Atorvastatin can be decreased when combined with Acetaminophen.
The metabolism of Atorvastatin can be decreased when combined with Acetazolamide.
The excretion of Atorvastatin can be decreased when combined with Acetylcysteine.
The serum concentration of Acetyldigoxin can be increased when it is combined with Atorvastatin.
Acipimox may increase the myopathic rhabdomyolysis activities of Atorvastatin.
The metabolism of Atorvastatin can be increased when combined with Adalimumab.
The metabolism of Atorvastatin can be decreased when combined with Adenine.
The metabolism of Atorvastatin can be increased when combined with Afelimomab.
The risk or severity of myopathy can be increased when Albaconazole is combined with Atorvastatin.
The metabolism of Atorvastatin can be decreased when combined with Aldesleukin.
40 References
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