Description

Simple

Clinical

Overview

Acetophenazine is an antipsychotic drug of moderate-potency. It is used in the treatment of disorganized and psychotic thinking. It is also used to help treat false perceptions (e.g. hallucinations or delusions). It primarily targets the dopamine D2 receptor.

Pharmacology

Indication

For the treatment of disorganized and psychotic thinking. Also used to help treat false perceptions (e.g. hallucinations or delusions.)

Pharmacodynamic

Acetophenzine is a phenothiazine antipsychotic intended for the management of schizophrenia and other psychotic disorders.

Mechanism of action

Acetophenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and e... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
2,5-Dimethoxy-4-ethylamphetamine
Acetophenazine may decrease the stimulatory activities of 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Acetophenazine may decrease the stimulatory activities of 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
Acetophenazine may decrease the stimulatory activities of 4-Bromo-2,5-dimethoxyamphetamine.
4-Methoxyamphetamine
The risk or severity of adverse effects can be increased when Acetophenazine is combined with 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of adverse effects can be increased when Acetophenazine is combined with 5-methoxy-N,N-dimethyltryptamine.
7-Nitroindazole
The risk or severity of adverse effects can be increased when Acetophenazine is combined with 7-Nitroindazole.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
The risk or severity of extrapyramidal symptoms can be increased when Acetophenazine is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Acebutolol
The serum concentration of Acebutolol can be increased when it is combined with Acetophenazine.
Acepromazine
The risk or severity of adverse effects can be increased when Acetophenazine is combined with Acepromazine.
Aceprometazine
The risk or severity of adverse effects can be increased when Acetophenazine is combined with Aceprometazine.
Acetazolamide
The risk or severity of adverse effects can be increased when Acetazolamide is combined with Acetophenazine.
Acetohexamide
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Acetophenazine.
Acetylglycinamide chloral hydrate
The risk or severity of adverse effects can be increased when Acetophenazine is combined with Acetylglycinamide chloral hydrate.
Aclidinium
Acetophenazine may increase the central nervous system depressant (CNS depressant) activities of Aclidinium.
Adinazolam
The risk or severity of adverse effects can be increased when Adinazolam is combined with Acetophenazine.
Adipiplon
The risk or severity of adverse effects can be increased when Acetophenazine is combined with Adipiplon.
Agomelatine
The risk or severity of adverse effects can be increased when Acetophenazine is combined with Agomelatine.
Ajulemic acid
The risk or severity of adverse effects can be increased when Ajulemic acid is combined with Acetophenazine.
Alaproclate
The risk or severity of adverse effects can be increased when Acetophenazine is combined with Alaproclate.
Alcuronium
The risk or severity of adverse effects can be increased when Acetophenazine is combined with Alcuronium.
2 References
  1. 1 . Jones GL, Woodbury DM: Spin-label study of phenothiazine interactions with erythrocyte ghost membranes: a possible membrane-mediated antisickling action. J Pharmacol Exp Ther. 1978 Oct;207(1):203-11.PubMed: 702341
  2. 2 . Tam SW, Cook L: Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes. Proc Natl Acad Sci U S A. 1984 Sep;81(17):5618-21.PubMed: 6147851