Amoxicillin


Description

A broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxicillin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it...

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Pharmacology

Indication

For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and... Read more

Pharmacodynamic

Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a li... Read more

Mechanism of action

Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well.... Read more

Absorption

Rapidly absorbed after oral administration.

Protein binding

In blood serum, amoxicillin is approximately 20% protein-bound

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

61.3 minutes

Route of elimination

Most of the amoxicillin is excreted unchanged in the urine; its excretion can be delayed by concurre... Read more

Toxicity

Serious toxicity is unlikely following large doses of amoxicillin. Acute ingestion of large doses of... Read more


Adverse Effects

Effect Regions Age Groups Incidences Evidence Type
Diarrhea US
  • Kind: experimental
    • Percent: 9%
  • Clinical Trial
    Loose stools US
  • Kind: experimental
    • Percent: 9%
  • Clinical Trial
    Diarrhea US
  • Kind: experimental
    • Percent: 8%
  • Clinical Trial
    Diarrhea US
    • pediatric
  • Kind: experimental
    • Percent: 3-8%
  • Clinical Trial
    Headache US
  • Kind: experimental
    • Percent: 7%
  • Clinical Trial
    Diarrhea US
  • Kind: experimental
    • Percent: 7%
  • Clinical Trial
    Diarrhea US
  • Kind: experimental
    • Percent: 7%
  • Clinical Trial
    Headache US
  • Kind: experimental
    • Percent: 6%
  • Clinical Trial
    Headache US
  • Kind: experimental
    • Percent: 6%
  • Clinical Trial
    Candidal infection US
    • pediatric
  • Kind: experimental
    • Percent: 4-6%
  • Clinical Trial
    Taste perversion US
  • Kind: experimental
    • Percent: 5%
  • Clinical Trial
    Taste perversion US
  • Kind: experimental
    • Percent: 5%
  • Clinical Trial
    Urticaria US
  • Kind: experimental
    • Percent: 3%
  • Clinical Trial
    Nausea US
  • Kind: experimental
    • Percent: 3%
  • Clinical Trial
    Skin rashes US
  • Kind: experimental
    • Percent: 3%
  • Clinical Trial
    Diarrhea US
  • Kind: experimental
    • Percent: >1%
  • Clinical Trial
    Nausea US
  • Kind: experimental
    • Percent: >1%
  • Clinical Trial
    Vomiting US
  • Kind: experimental
    • Percent: >1%
  • Clinical Trial
    Rash US
  • Kind: experimental
    • Percent: >1%
  • Clinical Trial
    Allergic Reaction US
    • pediatric
  • Kind: experimental
    • Percent: 1%
  • Clinical Trial
    Headache US
  • Kind: experimental
    • Percent: <1%
  • Clinical Trial
    Flatulence US
  • Kind: experimental
    • Percent: <1%
  • Clinical Trial
    Vaginitis US
  • Kind: experimental
    • Percent: 1%
  • Clinical Trial
    Abdominal Discomfort US
  • Kind: experimental
    • Percent: <1%
  • Clinical Trial
    Vomiting US
  • Kind: experimental
    • Percent: 1%
  • Clinical Trial
    Black hairy tongue US
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    Hemorrhagic Colitis US
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    Mucocutaneous candidiasis US
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    Serum sickness-like reactions US
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    Erythematous maculopapular rashes US
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    Pseudomembranous Colitis US
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    Anaphylaxis US
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    Thrombocytopenic Purpura US
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    Eosinophilia US
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    Leukopenia US
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    Agranulocytosis US
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    Reversible hyperactivity US
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    Agitation US
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    Anxiety US
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    Insomnia US
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    Confusion US
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    Convulsions US
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    Behavioral Changes US
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    Dizziness US
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    Tooth Discoloration US
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    Stevens-Johnson Syndrome US
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    Erythema multiforme US
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    Toxic Epidermal Necrolysis US
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    Exfoliative dermatitis US
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    Hypersensitivity Vasculitis US
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    Contraindications

    • Regions: US
    • Patient Conditions:
        • Name: Cholestatic jaundice
        • Drugbank Id: DBCOND0094562
    • Hypersensitivity:
      • beta-lactam antibiotics
    • Regions: US
    • Regions: US
    • Patient Conditions:
        • Name: Hepatic dysfunction
        • Drugbank Id: DBCOND0094733
    • Regions: US
    • Patient Conditions:
        • Name: Cholestatic jaundice
        • Drugbank Id: DBCOND0094562
    • Regions: US
    • Patient Conditions:
        • Name: Heptaic dysfunction
        • Drugbank Id: DBCOND0108177

    Food Interactions

    • Take without regard to meals.

    Interactions

    Type in a drug name to check for interaction with Amoxicillin

    Amoxicillin may increase the anticoagulant activities of (R)-warfarin.
    Amoxicillin may increase the anticoagulant activities of (S)-Warfarin.
    Amoxicillin may increase the anticoagulant activities of 4-hydroxycoumarin.
    Abacavir may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
    Acarbose may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
    Aceclofenac may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
    Acemetacin may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
    Amoxicillin may increase the anticoagulant activities of Acenocoumarol.
    Acetaminophen may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
    Acetazolamide may increase the excretion rate of Amoxicillin which could result in a lower serum level and potentially a reduction in efficacy.
    Acetylsalicylic acid may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
    Amoxicillin may decrease the excretion rate of Aclidinium which could result in a higher serum level.
    Amoxicillin may decrease the excretion rate of Acrivastine which could result in a higher serum level.
    Acyclovir may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
    Adefovir may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
    Adefovir dipivoxil may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
    The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Amoxicillin.
    Amoxicillin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
    Alclofenac may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
    The therapeutic efficacy of Alcuronium can be increased when used in combination with Amoxicillin.

    References

    • 1 . Drawz SM, Bonomo RA: Three decades of beta-lactamase inhibitors. Clin Microbiol Rev. 2010 Jan;23(1):160-201. doi: 10.1128/CMR.00037-09. [PubMed: 20065329]

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