Description

Simple

A medication used to treat cancers of the skin and white blood cells.

Clinical

An antineoplastic agent used to treat malignant melanoma and Hodgkin's disease.

Overview

An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.

Pharmacology

Indication

For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents.

Pharmacodynamic

Dacarbazine is a synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). After intravenous administration of dacarbazine, the volume of distribution exceeds total body water content suggesting localization in some body tissue, probably the liver. Its disapp... Read more

Mechanism of action

The mechanism of action is not known, but appears to exert cytotoxic effects via its action as an alkylating agent. Other theories include DNA synthesis inhibition by its action as a purine analog, and interaction with SH groups. Dacarbazine is not cell cycle-phase specific.

Absorption

Erratic, slow and incomplete.

Protein binding

Less than 5%

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

5 hours

Route of elimination

Dacarbazine is subject to renal tubular secretion rather than glomerular filtration. In man, dacarbazine is extensively degraded. Besides unchanged dacarbazine, 5-aminoimidazole -4 carboxamide (AIC) is a major metabolite of dacarbazine excreted in the urine.

Toxicity

LD50=350mg/kg (orally in mice)

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Dacarbazine
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The metabolism of (R)-warfarin can be decreased when combined with Dacarbazine.
(S)-Warfarin
The risk or severity of bleeding can be increased when (S)-Warfarin is combined with Dacarbazine.
2-Methoxyethanol
The risk or severity of adverse effects can be increased when Dacarbazine is combined with 2-Methoxyethanol.
4-hydroxycoumarin
The risk or severity of bleeding can be increased when 4-hydroxycoumarin is combined with Dacarbazine.
6-O-benzylguanine
The metabolism of 6-O-benzylguanine can be decreased when combined with Dacarbazine.
8-azaguanine
The metabolism of 8-azaguanine can be decreased when combined with Dacarbazine.
8-chlorotheophylline
The metabolism of 8-chlorotheophylline can be decreased when combined with Dacarbazine.
9-(N-methyl-L-isoleucine)-cyclosporin A
The risk or severity of adverse effects can be increased when Dacarbazine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
9-Deazaguanine
The metabolism of 9-Deazaguanine can be decreased when combined with Dacarbazine.
9-Methylguanine
The metabolism of 9-Methylguanine can be decreased when combined with Dacarbazine.
Abacavir
Dacarbazine may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abatacept
The metabolism of Dacarbazine can be increased when combined with Abatacept.
Abciximab
The risk or severity of bleeding can be increased when Abciximab is combined with Dacarbazine.
Abetimus
The risk or severity of adverse effects can be increased when Dacarbazine is combined with Abetimus.
Abiraterone
The serum concentration of Dacarbazine can be increased when it is combined with Abiraterone.
Acarbose
Acarbose may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Aceclofenac
Aceclofenac may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acefylline
The metabolism of Acefylline can be decreased when combined with Dacarbazine.
Acemetacin
Acemetacin may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acenocoumarol
The metabolism of Acenocoumarol can be decreased when combined with Dacarbazine.