Description

Simple

A medication used to temporarily treat high blood pressure.

Clinical

A dopamine D1 receptor agonist used for the short term management of hypertension.

Overview

A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation.

Pharmacology

Indication

For the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function.

Pharmacodynamic

Fenoldopam is an agonist at D1-like dopamine receptors, binds to α2-adrenoceptors, increasing renal blood flow.

Mechanism of action

Fenoldopam is a rapid-acting vasodilator. It is an agonist for D1-like dopamine receptors and binds with moderate affinity to α2-adrenoceptors. It has no significant affinity for D2-like receptors, α1 and β-adrenoceptors, 5HT1 a... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

The elimination half-life is about 5 minutes in mild to moderate hypertensives, with little difference between the R (active) and S isomers.

Route of elimination

Radiolabeled studies show that about 90% of infused fenoldopam is eliminated in urine, 10% in feces.
Elimination is largely by conjugation, without participation of cytochrome P-450 enzymes. Only 4% of the administered dose is excreted unchanged.

Toxicity

The most likely reaction of overdose would be excessive hypotension which should be treated with drug discontinuation and appropriate supportive measures.

Adverse Effects

Contraindications

  • Hypersensitivity:
    • false
  • Regions: US

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
1-benzylimidazole
1-benzylimidazole may decrease the antihypertensive activities of Fenoldopam.
2,5-Dimethoxy-4-ethylamphetamine
2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Fenoldopam.
2,5-Dimethoxy-4-ethylthioamphetamine
2,5-Dimethoxy-4-ethylthioamphetamine may decrease the antihypertensive activities of Fenoldopam.
4-Bromo-2,5-dimethoxyamphetamine
4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Fenoldopam.
4-Methoxyamphetamine
4-Methoxyamphetamine may decrease the antihypertensive activities of Fenoldopam.
5-methoxy-N,N-dimethyltryptamine
5-methoxy-N,N-dimethyltryptamine may decrease the antihypertensive activities of Fenoldopam.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Fenoldopam.
Abacavir
Fenoldopam may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abediterol
Abediterol may decrease the antihypertensive activities of Fenoldopam.
Acarbose
Acarbose may decrease the excretion rate of Fenoldopam which could result in a higher serum level.
Acebutolol
The therapeutic efficacy of Acebutolol can be increased when used in combination with Fenoldopam.
Aceclofenac
The therapeutic efficacy of Fenoldopam can be decreased when used in combination with Aceclofenac.
Acemetacin
The therapeutic efficacy of Fenoldopam can be decreased when used in combination with Acemetacin.
Acepromazine
The therapeutic efficacy of Fenoldopam can be decreased when used in combination with Acepromazine.
Aceprometazine
The therapeutic efficacy of Fenoldopam can be decreased when used in combination with Aceprometazine.
Acetaminophen
Acetaminophen may decrease the excretion rate of Fenoldopam which could result in a higher serum level.
Acetazolamide
Acetazolamide may increase the excretion rate of Fenoldopam which could result in a lower serum level and potentially a reduction in efficacy.
Acetophenazine
The therapeutic efficacy of Fenoldopam can be decreased when used in combination with Acetophenazine.
Acetylsalicylic acid
Acetylsalicylic acid may decrease the excretion rate of Fenoldopam which could result in a higher serum level.
Aclidinium
Fenoldopam may decrease the excretion rate of Aclidinium which could result in a higher serum level.