Description

Simple

Clinical

Overview

Haloprogin is used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affected, including tinea corporis (general skin), tinea cruris (groin), and tinea pedis (feet). Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but it is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. Haloprogin is no longer available in the United States and has been discontinued.

Pharmacology

Indication

Used to treat fungal (Tinea) skin infections such as athlete's foot, jock itch, ringworm, and tinea versicolor.

Pharmacodynamic

Used as a topical ointment or cream in the treatment of Tinea infections. Tinea infections are superficial fungal infections caused by three species of fungi collectively known as dermatophytes (Trichophyton, Microsporum and Epidermophyton). Commonly these infections are named for the body part affe... Read more

Mechanism of action

Haloprogin is a halogenated phenolic ether administered topically for dermotaphytic infections. The mechanism of action is unknown, but is thought to be via inhibition of oxygen uptake and disruption of yeast membrane structure and function. There is a higher incidence of cutaneous side effects with... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Haloprogin
Type a drug name in the box above to get started
  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The therapeutic efficacy of (R)-warfarin can be increased when used in combination with Haloprogin.
(S)-Warfarin
The therapeutic efficacy of (S)-Warfarin can be increased when used in combination with Haloprogin.
4-hydroxycoumarin
The therapeutic efficacy of 4-hydroxycoumarin can be increased when used in combination with Haloprogin.
Acenocoumarol
The therapeutic efficacy of Acenocoumarol can be increased when used in combination with Haloprogin.
Clorindione
The therapeutic efficacy of Clorindione can be increased when used in combination with Haloprogin.
Coumarin
The therapeutic efficacy of Coumarin can be increased when used in combination with Haloprogin.
Dicoumarol
The therapeutic efficacy of Dicoumarol can be increased when used in combination with Haloprogin.
Diphenadione
The therapeutic efficacy of Diphenadione can be increased when used in combination with Haloprogin.
Ethyl biscoumacetate
The therapeutic efficacy of Ethyl biscoumacetate can be increased when used in combination with Haloprogin.
Fluindione
The therapeutic efficacy of Fluindione can be increased when used in combination with Haloprogin.
Phenindione
The therapeutic efficacy of Phenindione can be increased when used in combination with Haloprogin.
Phenprocoumon
The therapeutic efficacy of Phenprocoumon can be increased when used in combination with Haloprogin.
Tioclomarol
The therapeutic efficacy of Tioclomarol can be increased when used in combination with Haloprogin.
Warfarin
The therapeutic efficacy of Warfarin can be increased when used in combination with Haloprogin.
2 References
  1. 1 . Harrison EF, Zwadyk P Jr, Bequette RJ, Hamlow EE, Tavormina PA, Zygmunt WA: Haloprogin: a topical antifungal agent. Appl Microbiol. 1970 May;19(5):746-50.PubMed: 5422306
  2. 2 . Harrison EF, Zygmunt WA: Haloprogin: mode of action studies in Candida albicans. Can J Microbiol. 1974 Sep;20(9):1241-5.PubMed: 4608935