Description

Simple

A medication used to improve the quality of images with an MRI.

Clinical

A gadolinium compound used as a contrast agent in MRIs.

Overview

A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see pentetic acid), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)

Pharmacology

Indication

For use with magnetic resonance imaging (MRI) in adults, and pediatric patients (2 years of age and older) to visualize lesions with abnormal vascularity in the brain (intracranial lesions), spine and associated tissues as well as lesions with abnormal vascularity in the head and neck. Also used to... Read more

Pharmacodynamic

Information currently not available.

Mechanism of action

Based on the behavior of protons when placed in a strong magnetic field, which is interpreted and transformed into images by magnetic resonance (MR) instruments. MR images are based primarily on proton density and proton relaxation dynamics. MR instruments are sensitive to two different relaxation p... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

266 ± 43 mL/kg

Clearance

1.94 +/- 0.28 mL/min/kg [Normal subjects]

Half life

Distribution half life 12 minutes, elimination half 100 minutes

Route of elimination

Gadopentetate is exclusively eliminated in the urine with 83 ± 14% (mean ± SD) of the dose excreted within 6 hours and 91 ± 13% (mean ± SD) by 24 hours, post-injection.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

  • Regions: US
  • Patient Conditions:
      • Name: Acute Kidney Injury
      • Drugbank Id: DBCOND0032980
      • Modification Of:
        • Base:
          • Name: Kidney Injury
          • Drugbank Id: DBCOND0039679
        • Severity:
          • Includes:
            • acute
  • Regions: US
  • Patient Conditions:
      • Name: Chronic, severe kidney disease
      • Drugbank Id: DBCOND0107818
      • Modification Of:
        • Base:
          • Name: Kidney Disease
          • Drugbank Id: DBCOND0027958
        • Severity:
          • Includes:
            • chronic
            • severe

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Gadopentetic acid
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
Abacavir
Gadopentetic acid may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acarbose
Acarbose may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Aceclofenac
Aceclofenac may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Acemetacin
Acemetacin may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Acetaminophen
Acetaminophen may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Acetazolamide
Acetazolamide may increase the excretion rate of Gadopentetic acid which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acid
Acetylsalicylic acid may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Aclidinium
Gadopentetic acid may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Gadopentetic acid may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir
Acyclovir may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Adefovir
Adefovir may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Adefovir dipivoxil
Adefovir dipivoxil may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Albutrepenonacog alfa
Gadopentetic acid may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Alclofenac
Alclofenac may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Aldesleukin
Aldesleukin may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Allopurinol
Allopurinol may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Allylestrenol
Gadopentetic acid may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
Almasilate
Gadopentetic acid may decrease the excretion rate of Almasilate which could result in a higher serum level.
Alminoprofen
Alminoprofen may decrease the excretion rate of Gadopentetic acid which could result in a higher serum level.
Almotriptan
Gadopentetic acid may decrease the excretion rate of Almotriptan which could result in a higher serum level.