Description

Simple

Clinical

Overview

Hetacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Hetacillin has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of Hetacillin results from the inhibition of cell wall synthesis and is mediated through Hetacillin binding to penicillin binding proteins (PBPs). Hetacillin has been withdrawn from the market since it has been discovered that it has no therapeutic advantage compared to non-ester derivatives like ampicillin.

Pharmacology

Indication

Hetacillin is a beta-lactam antibiotic prodrug used to treat bacterial infections. In the body it gets converted to ampicillin.

Pharmacodynamic

Hetacillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. He... Read more

Mechanism of action

Hetacillin is a semisynthetic penicillin prodrug which itself has no antibacterial activity, but is converted in the body to ampicillin and has actions and uses similar to those of ampicillin. Hetacillin is prepared by reacting ampicillin with acetone. Ampicillin rapidly decomposes because of the in... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The risk or severity of bleeding can be increased when Hetacillin is combined with (R)-warfarin.
(S)-Warfarin
The risk or severity of bleeding can be increased when Hetacillin is combined with (S)-Warfarin.
4-hydroxycoumarin
The risk or severity of bleeding can be increased when Hetacillin is combined with 4-hydroxycoumarin.
Acemetacin
Acemetacin may decrease the excretion rate of Hetacillin which could result in a higher serum level.
Acenocoumarol
The risk or severity of bleeding can be increased when Hetacillin is combined with Acenocoumarol.
Alcuronium
The therapeutic efficacy of Alcuronium can be increased when used in combination with Hetacillin.
Amikacin
The serum concentration of Amikacin can be decreased when it is combined with Hetacillin.
Apramycin
The serum concentration of Apramycin can be decreased when it is combined with Hetacillin.
Arbekacin
The serum concentration of Arbekacin can be decreased when it is combined with Hetacillin.
Atracurium
The therapeutic efficacy of Atracurium can be increased when used in combination with Hetacillin.
Atracurium besylate
The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Hetacillin.
BCG vaccine
The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Hetacillin.
Bekanamycin
The serum concentration of Bekanamycin can be decreased when it is combined with Hetacillin.
Capreomycin
The serum concentration of Capreomycin can be decreased when it is combined with Hetacillin.
Chlormadinone
The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Hetacillin.
Cinoxacin
The serum concentration of Cinoxacin can be increased when it is combined with Hetacillin.
Ciprofloxacin
The serum concentration of Ciprofloxacin can be increased when it is combined with Hetacillin.
Cisatracurium
The therapeutic efficacy of Cisatracurium can be increased when used in combination with Hetacillin.
Clomocycline
The therapeutic efficacy of Hetacillin can be decreased when used in combination with Clomocycline.
Cloprostenol
The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Hetacillin.