Description

Simple

A medication used to treat high blood pressure.

Clinical

A nicotine antagonist used to treat moderate to severe essential hypertension and uncomplicated malignant hypertension.

Overview

A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Mecamylamine has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool.

Pharmacology

Indication

For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension

Pharmacodynamic

Mecamylamine is a potent, oral antihypertensive agent and ganglion blocker, and is a secondary amine. Mecamylamine is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. Mecamylamine reduces blood pressure in both n... Read more

Mechanism of action

Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postur... Read more

Absorption

Mecamylamine is almost completely absorbed from the gastrointestinal tract

Protein binding

40%

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Mecamylamine is excreted slowly in the urine in the unchanged form. The rate of its renal elimination is influenced markedly by urinary pH.
Alkalinization of the urine reduces, and acidification promotes, renal excretion of mecamylamine. Mecamylamine crosses the blood-brain and placental barriers.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
1-benzylimidazole
1-benzylimidazole may decrease the antihypertensive activities of Mecamylamine.
1,10-Phenanthroline
The therapeutic efficacy of Mecamylamine can be decreased when used in combination with 1,10-Phenanthroline.
2,5-Dimethoxy-4-ethylamphetamine
2,5-Dimethoxy-4-ethylamphetamine may decrease the antihypertensive activities of Mecamylamine.
2,5-Dimethoxy-4-ethylthioamphetamine
2,5-Dimethoxy-4-ethylthioamphetamine may decrease the antihypertensive activities of Mecamylamine.
4-Bromo-2,5-dimethoxyamphetamine
4-Bromo-2,5-dimethoxyamphetamine may decrease the antihypertensive activities of Mecamylamine.
4-Methoxyamphetamine
4-Methoxyamphetamine may decrease the antihypertensive activities of Mecamylamine.
5-(2-methylpiperazine-1-sulfonyl)isoquinoline
The risk or severity of adverse effects can be increased when 5-(2-methylpiperazine-1-sulfonyl)isoquinoline is combined with Mecamylamine.
5-methoxy-N,N-dimethyltryptamine
5-methoxy-N,N-dimethyltryptamine may decrease the antihypertensive activities of Mecamylamine.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypotensive activities of Mecamylamine.
Abacavir
Mecamylamine may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abediterol
Abediterol may decrease the antihypertensive activities of Mecamylamine.
Acarbose
Acarbose may decrease the excretion rate of Mecamylamine which could result in a higher serum level.
Acebutolol
The therapeutic efficacy of Acebutolol can be increased when used in combination with Mecamylamine.
Aceclofenac
The therapeutic efficacy of Mecamylamine can be decreased when used in combination with Aceclofenac.
Acemetacin
The therapeutic efficacy of Mecamylamine can be decreased when used in combination with Acemetacin.
Acepromazine
Acepromazine may decrease the antihypertensive activities of Mecamylamine.
Acetaminophen
Acetaminophen may decrease the excretion rate of Mecamylamine which could result in a higher serum level.
Acetazolamide
The risk or severity of adverse effects can be increased when Acetazolamide is combined with Mecamylamine.
Acetyl sulfisoxazole
The risk or severity of adverse effects can be increased when Acetyl sulfisoxazole is combined with Mecamylamine.
Acetylsalicylic acid
Acetylsalicylic acid may decrease the excretion rate of Mecamylamine which could result in a higher serum level.