Description

Simple

A medication used to improve the quality of images with an MRI (magnetic resonance imaging) scan, a test that helps to see various parts of the body and find problems.

Clinical

A medication used to improve the contrast of MRI scans for better visualization.

Overview

Gadoteridol provides contrast enhancement of the brain, spine and surrounding tissues resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to cause a disruption of the normal blood brain barrier. Gadoteridol can also be used for whole body contrast enhanced MRI including the head, neck, liver, breast, musculoskeletal system and soft tissue pathologies. n MRI, visualization of normal and pathological brain tissue depends in part on variations in the radiofrequency signal intensity that occur with changes in proton density, alteration of the T1, and variation in T2. When placed in a magnetic field, gadoteridol shortens the T1 relaxation time in tissues where it accumulates. Abnormal vascularity or disruption of the blood-brain barrier allows accumulation of gadoteridol in lesions such as neoplasms, abscesses, and subacute infarcts.

Pharmacology

Indication

Gadoteridol is an MRI contrast agent used for contrast enhancement of the brain, spine and surrounding tissues resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to cause a disruption of the normal blood brain barrier. Gadoteridol... Read more

Pharmacodynamic

Information currently not available.

Mechanism of action

Based on the behavior of protons when placed in a strong magnetic field, which is interpreted and transformed into images by magnetic resonance (MR) instruments. Paramagnetic agents have unpaired electrons that generate a magnetic field about 700 times larger than the proton's field, thus disturbing... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

204 ± 58 mL/kg

Clearance

1.50+/- 0.35 mL/ min/kgrenal cl=1.41 +/- 0.33 mL/ min/kg

Half life

Distribution 12 minutes (mean), elimination 100 minutes (mean).

Route of elimination

Gadoteridol is eliminated in the urine with 94.4 ± 4.8% (mean ± SD) of the dose excreted within 24 hours post-injection.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
Abacavir
Gadoteridol may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acarbose
Acarbose may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Aceclofenac
Aceclofenac may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Acemetacin
Acemetacin may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Acetaminophen
Acetaminophen may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Acetazolamide
Acetazolamide may increase the excretion rate of Gadoteridol which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acid
Acetylsalicylic acid may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Aclidinium
Gadoteridol may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Gadoteridol may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir
Acyclovir may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Adefovir
Adefovir may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Adefovir dipivoxil
Adefovir dipivoxil may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Albutrepenonacog alfa
Gadoteridol may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Alclofenac
Alclofenac may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Aldesleukin
Aldesleukin may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Allopurinol
Allopurinol may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Allylestrenol
Gadoteridol may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
Almasilate
Gadoteridol may decrease the excretion rate of Almasilate which could result in a higher serum level.
Alminoprofen
Alminoprofen may decrease the excretion rate of Gadoteridol which could result in a higher serum level.
Almotriptan
Gadoteridol may decrease the excretion rate of Almotriptan which could result in a higher serum level.