Description

Simple

A medication used to treat acid reflux (heartburn) and ulcers.

Clinical

An H2 receptor antagonist used to treat GERD and a variety of ulcers.

Overview

A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.

Pharmacology

Indication

For the treatment of acid-reflux disorders (GERD), peptic ulcer disease, active benign gastric ulcer, and active duodenal ulcer.

Pharmacodynamic

Nizatidine is a competitive, reversible inhibitor of histamine at the histamine H2-receptors, particularly those in the gastric parietal cells. By inhibiting the action of histamine on stomach cells, nizatidine reduces stomach acid production. Nizatidine had no demonstrable antiandrogenic action. Fu... Read more

Mechanism of action

Nizatidine competes with histamine for binding at the H2-receptors on the gastric basolateral membrane of parietal cells. Competitive inhibition results in reduction of basal and nocturnal gastric acid secretions. The drug also decreases the gastric acid response to stimuli such as food,... Read more

Absorption

Rapid (bioavailability of nizatidine exceeds 70%)

Protein binding

35%

Volume of distribution

0.8 to 1.5 L/kg

Clearance

40-60 L/h7 – 14 L/h [functionally anephric patients]

Half life

1-2 hours

Route of elimination

Information currently not available.

Toxicity

Oral, rat LD50: 301 mg/kg. Symptoms of overdose include cholinergic-type effects including lacrimation, salivation, emesis, miosis, and diarrhea.

Adverse Effects

Contraindications

  • Hypersensitivity:
    • H2 Antagonists
  • Regions: US

Food Interactions

  • Avoid alcohol.
  • Do not take Aluminum or magnesium antacids or supplements while on this medication.
  • Limit caffeine intake.
  • May take Vitamin D.
  • No iron, zinc or fluoride within 2 hours of taking this medication.
  • Take with or without food. The absorption is unaffected by food.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
2,5-Dimethoxy-4-ethylamphetamine
2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative and stimulatory activities of Nizatidine.
2,5-Dimethoxy-4-ethylthioamphetamine
2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative and stimulatory activities of Nizatidine.
4-Bromo-2,5-dimethoxyamphetamine
4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative and stimulatory activities of Nizatidine.
Abafungin
Nizatidine can cause a decrease in the absorption of Abafungin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Abemaciclib
The serum concentration of Nizatidine can be increased when it is combined with Abemaciclib.
Acebutolol
The serum concentration of Acebutolol can be increased when it is combined with Nizatidine.
Acetaminophen
The serum concentration of Nizatidine can be increased when it is combined with Acetaminophen.
Acetylcholine
The risk or severity of adverse effects can be increased when Nizatidine is combined with Acetylcholine.
Acetylsalicylic acid
The serum concentration of Acetylsalicylic acid can be increased when it is combined with Nizatidine.
Acipimox
The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nizatidine is combined with Acipimox.
Aclidinium
The therapeutic efficacy of Aclidinium can be decreased when used in combination with Nizatidine.
Afatinib
The serum concentration of Nizatidine can be increased when it is combined with Afatinib.
Agmatine
The therapeutic efficacy of Agmatine can be decreased when used in combination with Nizatidine.
Albaconazole
Nizatidine can cause a decrease in the absorption of Albaconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Albendazole
The serum concentration of Nizatidine can be increased when it is combined with Albendazole.
Alcuronium
Nizatidine may decrease the neuromuscular blocking activities of Alcuronium.
Aldosterone
The serum concentration of Aldosterone can be increased when it is combined with Nizatidine.
Alectinib
The serum concentration of Nizatidine can be increased when it is combined with Alectinib.
Alendronic acid
The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nizatidine is combined with Alendronic acid.
Alfentanil
The serum concentration of Nizatidine can be increased when it is combined with Alfentanil.