Description

Simple

A medication used to treat obesity when combined with lifestyle changes like diet and exercise.

Clinical

A sympathomimetic used to treat obesity in combination with lifestyle modifications.

Overview

Mazindol is a tricyclic anorexigenic agent that is unrelated to and less toxic than [amphetamine], but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter. Mazindol is only approved in the United States for the treatment of Duchenne muscular dystrophy, and is not marketed or available in the United States for use in the treatment of obesity.

Pharmacology

Indication

Used in short-term (a few weeks) treatment of exogenous obesity in conjunction with a regimen of weight reduction based on caloric restriction, exercise, and behavior modification in patients with a body mass index of 30 kg of body weight per height in meters squared (kg/m2) or in patient... Read more

Pharmacodynamic

Mazindol is a sympathomimetic amine that stimulates the central nervous system (nerves and brain), leading to increased your heart rate and blood pressure, and decreased appetite. Since the appetite-suppressing effect of the drug tends to decrease after few weeks of treatment, sympathomimetic appeti... Read more

Mechanism of action

Unlike other sympathomimetic appetite suppressants such as phentermine, mazindol is thought to inhibit the reuptake of norepinephrine rather than to cause its release.

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

10-13 hours

Route of elimination

Information currently not available.

Toxicity

Symptoms of mazindol overdose may be associated with restlessness, tremor, rapid breathing, confusion, hallucinations, panic, aggressiveness, nausea, vomiting, diarrhea, an irregular heartbeat, and seizures.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

  • Take with or without food. Preferably take 1 hour before a meal. Taking with food may reduce GI disturbance.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The risk or severity of adverse effects can be increased when Mazindol is combined with (R)-warfarin.
(S)-Warfarin
The risk or severity of adverse effects can be increased when Mazindol is combined with (S)-Warfarin.
2,5-Dimethoxy-4-ethylamphetamine
The risk or severity of serotonin syndrome can be increased when Mazindol is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
The risk or severity of adverse effects can be increased when Mazindol is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
The risk or severity of adverse effects can be increased when Mazindol is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-hydroxycoumarin
The risk or severity of adverse effects can be increased when Mazindol is combined with 4-hydroxycoumarin.
4-Methoxyamphetamine
The risk or severity of adverse effects can be increased when Mazindol is combined with 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of adverse effects can be increased when Mazindol is combined with 5-methoxy-N,N-dimethyltryptamine.
6-hydroxydopa quinone
The risk or severity of adverse effects can be increased when Mazindol is combined with 6-hydroxydopa quinone.
7-Nitroindazole
The risk or severity of adverse effects can be increased when Mazindol is combined with 7-Nitroindazole.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
The risk or severity of adverse effects can be increased when Mazindol is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Acenocoumarol
The risk or severity of adverse effects can be increased when Mazindol is combined with Acenocoumarol.
Acepromazine
The risk or severity of adverse effects can be increased when Mazindol is combined with Acepromazine.
Aceprometazine
The risk or severity of adverse effects can be increased when Mazindol is combined with Aceprometazine.
Acetazolamide
The risk or severity of adverse effects can be increased when Mazindol is combined with Acetazolamide.
Acetophenazine
The risk or severity of adverse effects can be increased when Mazindol is combined with Acetophenazine.
Acetylglycinamide chloral hydrate
The risk or severity of adverse effects can be increased when Mazindol is combined with Acetylglycinamide chloral hydrate.
Aclidinium
Mazindol may increase the central nervous system depressant (CNS depressant) activities of Aclidinium.
Adinazolam
The risk or severity of adverse effects can be increased when Adinazolam is combined with Mazindol.
Adipiplon
The risk or severity of adverse effects can be increased when Mazindol is combined with Adipiplon.