Description

Simple

Clinical

Overview

Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.

Pharmacology

Indication

For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.

Pharmacodynamic

Carbenicillin is a semisynthetic penicillin. Though carbenicillin provides substantial in vitro activity against a variety of both gram-positive and gram-negative microorganisms, the most important aspect of its profile is in its antipseudomonal and antiproteal activity. Because of the high u... Read more

Mechanism of action

Free carbenicillin is the predominant pharmacologically active fraction of the salt. Carbenicillin exerts its antibacterial activity by interference with final cell wall synthesis of susceptible bacteria. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the la... Read more

Absorption

Rapidly absorbed from the small intestine following oral administration. Oral bioavailability is 30 to 40%.

Protein binding

30 to 60%

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

1 hour

Route of elimination

Information currently not available.

Toxicity

Carbenicillin blood levels achievable are very low, and toxic reactions as a function of overdosage should not occur systematically. The oral LD50 in mice is 3,600 mg/kg, in rats 2,000 mg/kg, and in dogs is in excess of 500 mg/kg. The lethal human dose is not known. Symptoms of overdose i... Read more

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

  • Take on an empty stomach.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
Carbenicillin may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Carbenicillin may increase the anticoagulant activities of (S)-Warfarin.
4-hydroxycoumarin
Carbenicillin may increase the anticoagulant activities of 4-hydroxycoumarin.
Acemetacin
Acemetacin may decrease the excretion rate of Carbenicillin which could result in a higher serum level.
Acenocoumarol
Carbenicillin may increase the anticoagulant activities of Acenocoumarol.
Acyclovir
The excretion of Acyclovir can be decreased when combined with Carbenicillin.
Adefovir dipivoxil
The excretion of Adefovir dipivoxil can be decreased when combined with Carbenicillin.
Alcuronium
The therapeutic efficacy of Alcuronium can be increased when used in combination with Carbenicillin.
Alprostadil
The excretion of Alprostadil can be decreased when combined with Carbenicillin.
Amikacin
The serum concentration of Amikacin can be decreased when it is combined with Carbenicillin.
Aminohippuric acid
The excretion of Aminohippuric acid can be decreased when combined with Carbenicillin.
Apramycin
The serum concentration of Apramycin can be decreased when it is combined with Carbenicillin.
Arbekacin
The serum concentration of Arbekacin can be decreased when it is combined with Carbenicillin.
Atracurium
The therapeutic efficacy of Atracurium can be increased when used in combination with Carbenicillin.
Atracurium besylate
The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Carbenicillin.
BCG vaccine
The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Carbenicillin.
Bekanamycin
The serum concentration of Bekanamycin can be decreased when it is combined with Carbenicillin.
Capreomycin
The serum concentration of Capreomycin can be decreased when it is combined with Carbenicillin.
Captopril
The excretion of Captopril can be decreased when combined with Carbenicillin.
Cefacetrile
The excretion of Cefacetrile can be decreased when combined with Carbenicillin.