Description

Simple

A medication used to suppress the appetite and assist in weight loss.

Clinical

An appetite suppressant used to assist in weight loss for obese patients.

Overview

Fenfluramine is an appetite suppressant that was previously used in the treatment of obesity. After reports of heart valve disease and pulmonary hypertension, including a condition known as cardiac fibrosis, it was withdrawn from the U.S. market in 1997 due to safety reasons.

Pharmacology

Indication

For the management of exogenous obesity as a short-term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction.

Pharmacodynamic

Used to treat obesity, Fenfluramine decreases caloric intake by increasing serotonin levels in the brain's synapses. Fenfluramine acts as a serotonin reuptake inhibitor. It also causes release of serotonin from the synaptosomes. This in turn increases serotonin transmission in the feeding centre of... Read more

Mechanism of action

Fenfluramine binds to the serotonin reuptake pump. This causes inhbition of serotonin uptake and release of serotonin. The increased levels of serotonin lead to greater serotonin receptor activation which in turn lead to enhancement of serotoninergic transmission in the centres of feeding behavior l... Read more

Absorption

Fenfluramine is well-absorbed from the gastrointestinal tract, and a maximal anorectic effect is generally seen after 2 to 4 hours.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

20 hours

Route of elimination

Information currently not available.

Toxicity

Agitation and drowsiness, confusion, flushing, tremor (or shivering), fever, sweating, abdominal pain, hyperventilation, and dilated non-reactive pupils seem frequent in fenfluramine overdosage. Reflexes may be either exaggerated or depressed and some patients may have rotary nystagmus. Tachycardia... Read more

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

  • Take with or without food. The absorption is unaffected by food.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The risk or severity of adverse effects can be increased when Fenfluramine is combined with (R)-warfarin.
(S)-Warfarin
The risk or severity of adverse effects can be increased when Fenfluramine is combined with (S)-Warfarin.
2,5-Dimethoxy-4-ethylamphetamine
The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
The risk or severity of adverse effects can be increased when Fenfluramine is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
The risk or severity of adverse effects can be increased when Fenfluramine is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-hydroxycoumarin
The risk or severity of adverse effects can be increased when Fenfluramine is combined with 4-hydroxycoumarin.
4-Methoxyamphetamine
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Fenfluramine.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of adverse effects can be increased when Fenfluramine is combined with 5-methoxy-N,N-dimethyltryptamine.
7-Nitroindazole
The risk or severity of adverse effects can be increased when Fenfluramine is combined with 7-Nitroindazole.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
The risk or severity of adverse effects can be increased when Fenfluramine is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Acebutolol
The metabolism of Acebutolol can be decreased when combined with Fenfluramine.
Acenocoumarol
The risk or severity of adverse effects can be increased when Fenfluramine is combined with Acenocoumarol.
Acepromazine
The risk or severity of adverse effects can be increased when Fenfluramine is combined with Acepromazine.
Aceprometazine
The risk or severity of adverse effects can be increased when Fenfluramine is combined with Aceprometazine.
Acetaminophen
The metabolism of Acetaminophen can be decreased when combined with Fenfluramine.
Acetazolamide
The risk or severity of adverse effects can be increased when Fenfluramine is combined with Acetazolamide.
Acetophenazine
The risk or severity of adverse effects can be increased when Fenfluramine is combined with Acetophenazine.
Acetylglycinamide chloral hydrate
The risk or severity of adverse effects can be increased when Fenfluramine is combined with Acetylglycinamide chloral hydrate.
Aclidinium
Fenfluramine may increase the central nervous system depressant (CNS depressant) activities of Aclidinium.
Adinazolam
The risk or severity of adverse effects can be increased when Adinazolam is combined with Fenfluramine.
1 References
  1. 1 . Roth BL: Drugs and valvular heart disease. N Engl J Med. 2007 Jan 4;356(1):6-9.PubMed: 17202450