Description

Simple

A painkiller used to treat mild to moderate pain as well as arthritis symptoms.

Clinical

An anti-inflammatory analgesic used to treat mild to moderate pain in addition to the signs and symptoms of rheumatoid arthritis and osteoarthritis.

Overview

An anti-inflammatory analgesic and antipyretic highly bound to plasma proteins. It is pharmacologically similar to aspirin, but causes less gastrointestinal bleeding.

Pharmacology

Indication

For relief of the signs and symptoms of rheumatoid arthritis and osteoarthritis. Also for the relief of mild to moderate pain.

Pharmacodynamic

Fenoprofen is a propionic acid derivative with analgesic, antiinflammatory and antipyretic properties. Fenoprofen inhibits prostaglandin synthesis by decreasing the enzyme needed for biosynthesis. In patients with rheumatoid arthritis, the anti-inflammatory action of fenoprofen has been evidenced by... Read more

Mechanism of action

Fenoprofen's exact mode of action is unknown, but it is thought that prostaglandin synthetase inhibition is involved. Fenoprofen has been shown to inhibit prostaglandin synthetase isolated from bovine seminal vesicles.

Absorption

Rapidly absorbed under fasting conditions, and peak plasma levels of 50 µg/mL are achieved within 2 hours after oral administration of 600 mg doses.

Protein binding

99% to albumin.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Plasma half-life is approximately 3 hours.

Route of elimination

Information currently not available.

Toxicity

Symptoms of overdose appear within several hours and generally involve the gastrointestinal and central nervous systems. They include dyspepsia, nausea, vomiting, abdominal pain, dizziness, headache, ataxia, tinnitus, tremor, drowsiness, and confusion. Hyperpyrexia, tachycardia, hypotension, and acu... Read more

Adverse Effects

Contraindications

  • Regions: US
  • With Therapies:
      • Name: Coronary artery bypass graft (CABG) surgery
      • Drugbank Id: DBCOND0107829
  • Hypersensitivity:
    • aspirin
    • Anti-Inflammatory Agents, Non-Steroidal
  • Regions: US

Food Interactions

  • Avoid alcohol.
  • Take with food. Food reduces irritation.

Interactions

Type in a drug name to check for interaction with Fenoprofen
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with (R)-warfarin.
(S)-Warfarin
The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with (S)-Warfarin.
1-benzylimidazole
The risk or severity of hypertension can be increased when Fenoprofen is combined with 1-benzylimidazole.
2,5-Dimethoxy-4-ethylamphetamine
The risk or severity of hypertension can be increased when Fenoprofen is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
The risk or severity of hypertension can be increased when Fenoprofen is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
The risk or severity of hypertension can be increased when Fenoprofen is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-hydroxycoumarin
The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with 4-hydroxycoumarin.
4-Methoxyamphetamine
The risk or severity of hypertension can be increased when Fenoprofen is combined with 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of hypertension can be increased when Fenoprofen is combined with 5-methoxy-N,N-dimethyltryptamine.
Abacavir
Fenoprofen may decrease the excretion rate of Abacavir which could result in a higher serum level.
Abciximab
The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with Abciximab.
Abediterol
The risk or severity of hypertension can be increased when Fenoprofen is combined with Abediterol.
Acarbose
Fenoprofen may decrease the excretion rate of Acarbose which could result in a higher serum level.
Acebutolol
Fenoprofen may decrease the antihypertensive activities of Acebutolol.
Aceclofenac
The risk or severity of adverse effects can be increased when Fenoprofen is combined with Aceclofenac.
Acemetacin
The risk or severity of adverse effects can be increased when Fenoprofen is combined with Acemetacin.
Acenocoumarol
The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with Acenocoumarol.
Acepromazine
The risk or severity of hypertension can be increased when Fenoprofen is combined with Acepromazine.
Acetaminophen
The risk or severity of adverse effects can be increased when Acetaminophen is combined with Fenoprofen.
Acetohexamide
The protein binding of Acetohexamide can be decreased when combined with Fenoprofen.