Description

Simple

A medication used to improve the quality of images during a scan to see certain parts of the body, which is known as an MRI (or magnetic resonance imaging).

Clinical

A gadolinium compound used as a contrast agent in MRI tests of the brain, spine, and liver.

Overview

Gadoversetamide, marketed under the trade name OptiMARK, is a gadolinium compound used as a contrast agent in magnetic resonance imaging (MRI), particularly imaging of the brain, spine and liver.

Pharmacology

Indication

Gadoversetamide is an MRI contrast agent used for MRI diagnostic procedures to provide increased enhancement and visualization of lesions of the brain, spine and liver, including tumors.

Pharmacodynamic

Information currently not available.

Mechanism of action

Based on the behavior of protons when placed in a strong magnetic field, which is interpreted and transformed into images by magnetic resonance (MR) instruments. MR images are based primarily on proton density and proton relaxation dynamics. MR instruments are sensitive to two different relaxation p... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

162 ± 25 mL/kg [normal subjects]

Clearance

72 +/- 16.3 mL/hr/kg [healthy]

Half life

Distribution 13.3 ± 6.8 (mean) minutes, elimination 103.6 ± 19.5 (mean) minutes.

Route of elimination

The mean cumulative urinary excretion of gadoversetamide at 72 hours was approximately 93.5% for renal impaired patients and 95.8% for subjects with normal renal function

Toxicity

Information currently not available.

Adverse Effects

Contraindications

  • Route:
    • Intravenous
  • Hypersensitivity:
    • gadolinum
    • versetamide
  • Regions: US
  • Route:
    • Intravenous
  • Regions: US
  • Patient Conditions:
      • Name: Chronic, severe kidney disease
      • Drugbank Id: DBCOND0107818
      • Modification Of:
        • Base:
          • Name: Kidney Disease
          • Drugbank Id: DBCOND0027958
        • Severity:
          • Includes:
            • chronic
            • severe
  • Route:
    • Intravenous
  • Regions: US
  • Patient Conditions:
      • Name: Acute Kidney Injury
      • Drugbank Id: DBCOND0032980
      • Modification Of:
        • Base:
          • Name: Kidney Injury
          • Drugbank Id: DBCOND0039679
        • Severity:
          • Includes:
            • acute

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)