Description

Simple

A medication used with anesthesia medications to relax muscles during surgery.

Clinical

A nondepolarizing nerve blocker used in addition to anesthesia to cause skeletal muscle relaxation.

Overview

A synthetic nondepolarizing blocking drug. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. It should be used cautiously in patients at risk from increased heart rate but may be preferred for patients with bradycardia. (From AMA Drug Evaluations Annual, 1992, p198)

Pharmacology

Indication

For use as adjuncts to anesthesia to induce skeletal muscle relaxation and to facilitate the management of patients undergoing mechanical ventilation

Pharmacodynamic

Gallamine Triethiodide is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia a... Read more

Mechanism of action

It competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. It blocks the act... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Gallamine triethiodide
Type a drug name in the box above to get started
  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
1,10-Phenanthroline
1,10-Phenanthroline may decrease the neuromuscular blocking activities of Gallamine triethiodide.
2,5-Dimethoxy-4-ethylamphetamine
The risk or severity of Tachycardia can be increased when Gallamine triethiodide is combined with 2,5-Dimethoxy-4-ethylamphetamine.
2,5-Dimethoxy-4-ethylthioamphetamine
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with 4-Bromo-2,5-dimethoxyamphetamine.
4-Methoxyamphetamine
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with 5-methoxy-N,N-dimethyltryptamine.
7-Nitroindazole
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with 7-Nitroindazole.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Abediterol
The risk or severity of Tachycardia can be increased when Gallamine triethiodide is combined with Abediterol.
Acebutolol
Gallamine triethiodide may increase the bradycardic activities of Acebutolol.
Acepromazine
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Acepromazine.
Aceprometazine
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Aceprometazine.
Acetazolamide
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Acetazolamide.
Acetophenazine
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Acetophenazine.
Acetylcholine
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Acetylcholine.
Acetyldigitoxin
The risk or severity of Cardiac Arrhythmia can be increased when Gallamine triethiodide is combined with Acetyldigitoxin.
Acetyldigoxin
The risk or severity of Cardiac Arrhythmia can be increased when Gallamine triethiodide is combined with Acetyldigoxin.
Acetylglycinamide chloral hydrate
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Acetylglycinamide chloral hydrate.
Aclidinium
The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Aclidinium.
Acotiamide
Acotiamide may decrease the neuromuscular blocking activities of Gallamine triethiodide.