Loratadine


Description

Loratadine is a second generation antihistamine used to manage symptoms of allergic rhinitis. [

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Pharmacology

Indication

Loratadine is a 2nd generation antihistamine and is typically used to manage symptoms of allergic rh... Read more

Pharmacodynamic

As a 2nd generation antihistamine, loratadine is selective for peripheral H1 receptors allowing it t... Read more

Mechanismofaction

Loratadine binds to H1 histamine receptors found on the surface of various cells including epithelia... Read more

Absorption

Loratadine is rapidly absorbed and achieves peak plasma concentration in 1-2 hours, while it's main... Read more

Proteinbinding

97 - 99% of the loratadine is bound to plasma proteins.[ Read more

Volumeofdistribution

The volume of distribution of loratadine is 120 L/Kg. [ Read more

Clearance

Interestingly, P-glycoprotein appears to be involved in the clearance of many 2nd generation antihis... Read more

Halflife

The elimination half life is approximately 10 hours for loratadine and 20 hours for descarbethoxylor... Read more

Routeofelimination

Over a 10 day period, 40% of loratadine is excreted in the urine, while 42% is eliminated in the fae... Read more

Toxicity

Second generation antihistamines such as loratadine have very few adverse effects; however, insomnia... Read more


Adverse Effects

Effect Regions Age Groups Incidences Evidence Type
Headache US
  • Kind: experimental
    • Percent: 12
  • Somnolence/fatigue US
  • Kind: experimental
    • Percent: 8
  • Fatigue Symptom US
  • Kind: experimental
    • Percent: 4
  • Wheezing US
  • Kind: experimental
    • Percent: 4
  • Nervousness US
  • Kind: experimental
    • Percent: 4
  • Hyperkinesia US
  • Kind: experimental
    • Percent: 3
  • General fatigue US
  • Kind: experimental
    • Percent: 3
  • Dry Mouth US
  • Kind: experimental
    • Percent: 3
  • Malaise US
  • Kind: experimental
    • Percent: 2
  • Upper Respiratory Tract Infection US
  • Kind: experimental
    • Percent: 2
  • Dysphonia US
  • Kind: experimental
    • Percent: 2
  • Conjunctivitis US
  • Kind: experimental
    • Percent: 2
  • Abdominal Pain US
  • Kind: experimental
    • Percent: 2

  • Contraindications

    • Regions: US
    • Patient Conditions:
        • Name: Hypersensitivity Reaction
        • Drugbank Id: DBCOND0053862

    Food Interactions

    • Take on empty stomach: 1 hour before or 2 hours after meals.

    Interactions

    Type in a drug name to check for interaction with Loratadine

    The metabolism of (R)-warfarin can be increased when combined with Loratadine.
    The metabolism of (S)-Warfarin can be increased when combined with Loratadine.
    2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative and stimulatory activities of Loratadine.
    2,5-Dimethoxy-4-ethylthioamphetamine may decrease the sedative and stimulatory activities of Loratadine.
    The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Loratadine.
    4-Bromo-2,5-dimethoxyamphetamine may decrease the sedative and stimulatory activities of Loratadine.
    The risk or severity of adverse effects can be increased when Loratadine is combined with 4-Bromo-2,5-dimethoxyphenethylamine.
    The metabolism of 4-hydroxycoumarin can be increased when combined with Loratadine.
    The risk or severity of adverse effects can be increased when Loratadine is combined with 4-Methoxyamphetamine.
    The metabolism of 5-androstenedione can be increased when combined with Loratadine.
    The risk or severity of adverse effects can be increased when Loratadine is combined with 5-methoxy-N,N-dimethyltryptamine.
    The metabolism of Loratadine can be decreased when combined with 6-Deoxyerythronolide B.
    The metabolism of 6-O-benzylguanine can be increased when combined with Loratadine.
    The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Loratadine.
    The risk or severity of adverse effects can be increased when Loratadine is combined with 7-Nitroindazole.
    The risk or severity of adverse effects can be increased when Loratadine is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
    The metabolism of 9-aminocamptothecin can be increased when combined with Loratadine.
    The metabolism of Loratadine can be increased when combined with Abatacept.
    The serum concentration of Abemaciclib can be increased when it is combined with Loratadine.
    The risk or severity of QTc prolongation can be increased when Loratadine is combined with Abexinostat.

    References

    • 1 . See S: Desloratadine for allergic rhinitis. Am Fam Physician. 2003 Nov 15;68(10):2015-6. [PubMed: 14655812]
    • 2 . Menardo JL, Horak F, Danzig MR, Czarlewski W: A review of loratadine in the treatment of patients with allergic bronchial asthma. Clin Ther. 1997 Nov-Dec;19(6):1278-93; discussion 1523-4. [PubMed: 9444440]
    • 3 . Howarth PH: Histamine and asthma: an appraisal based on specific H1-receptor antagonism. Clin Exp Allergy. 1990 Aug;20 Suppl 2:31-41. [PubMed: 1977506]
    • 4 . Baroody FM, Naclerio RM: Antiallergic effects of H1-receptor antagonists. Allergy. 2000;55 Suppl 64:17-27. [PubMed: 11291777]
    • 5 . Tenn MW, Steacy LM, Ng CC, Ellis AK: Onset of action for loratadine tablets for the symptomatic control of seasonal allergic rhinitis in adults challenged with ragweed pollen in the Environmental Exposure Unit: a post hoc analysis of total symptom score. Allergy Asthma Clin Immunol. 2018 Jan 16;14:5. doi: 10.1186/s13223-017-0227-4. eCollection 2018. [PubMed: 29371864]
    • 6 . Barenholtz HA, McLeod DC: Loratadine: a nonsedating antihistamine with once-daily dosing. DICP. 1989 Jun;23(6):445-50. [PubMed: 2525847]
    • 7 . Randall KL, Hawkins CA: Antihistamines and allergy. Aust Prescr. 2018 Apr;41(2):41-45. doi: 10.18773/austprescr.2018.013. Epub 2018 Apr 3. [PubMed: 29670310]
    • 8 . Church MK, Church DS: Pharmacology of antihistamines. Indian J Dermatol. 2013 May;58(3):219-24. doi: 10.4103/0019-5154.110832. [PubMed: 23723474]
    • 9 . Clissold SP, Sorkin EM, Goa KL: Loratadine. A preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs. 1989 Jan;37(1):42-57. [PubMed: 2523301]
    • 10 . Ghosal A, Gupta S, Ramanathan R, Yuan Y, Lu X, Su AD, Alvarez N, Zbaida S, Chowdhury SK, Alton KB: Metabolism of loratadine and further characterization of its in vitro metabolites. Drug Metab Lett. 2009 Aug;3(3):162-70. Epub 2009 Aug 1. [PubMed: 19702548]
    • 11 . Zhang YF, Chen XY, Zhong DF, Dong YM: Pharmacokinetics of loratadine and its active metabolite descarboethoxyloratadine in healthy Chinese subjects. Acta Pharmacol Sin. 2003 Jul;24(7):715-8. [PubMed: 12852841]
    • 12 . Claritin Packaging Label [File]
    • 13 . Claritin Product Monograph [File]
    • 14 . Comparative Pharmacology of the H1 Antihistamines [File]

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