Description

Simple

A medication used to treat cold sores and genital herpes in people with and without HIV infection, and to treat shingles (also known as herpes zoster).

Clinical

A nucleoside analog DNA polymerase inhibitor used for the treatment of recurrent cold sores and genital herpes in healthy patients and patients with HIV, and to manage herpes zoster.

Overview

Famciclovir, marketed as Famvir by Novartis, is a guanine analogue used to treat herpes virus infections. It is most commonly used to treat herpes zoster (shingles). Famciclovir is a prodrug of penciclovir with higher oral bioavailability.

Pharmacology

Indication

For the treatment of acute herpes zoster (shingles). Also for the treatment or suppression of recurrent genital herpes in immunocompetent patients and treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients.

Pharmacodynamic

Famciclovir is a prodrug that undergoes rapid biotransformation to the active antiviral compound penciclovir. Penciclovir is an anti-viral drug which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). Therefore, herpes viral DNA synth... Read more

Mechanism of action

Famciclovir undergoes rapid biotransformation to the active antiviral compound penciclovir, which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). In cells infected with HSV-1, HSV-2 or VZV, viral thymidine kinase phosphorylates pen... Read more

Absorption

77 %

Protein binding

20-25%

Volume of distribution

1.08±0.17 L/kg [healthy male subjects following a single intravenous dose of penciclovir at 400 mg administered as a 1-hour intravenous infusion]

Clearance

36.6 +/- 6.3 L/hr [healthy male]0.48 +/- 0.09 L/hr/kg [healthy male]

Half life

10 hours

Route of elimination

Active tubular secretion contributes to the renal elimination of penciclovir.

Toxicity

Symptoms of overdose include constipation, diarrhea, dizziness, fatigue, fever, headache, nausea, and vomiting.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

  • Take with or without food. The absorption is unaffected by food.

Interactions

Type in a drug name to check for interaction with Famciclovir
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
4-hydroxycoumarin
The metabolism of 4-hydroxycoumarin can be decreased when combined with Famciclovir.
6-Deoxyerythronolide B
The metabolism of Famciclovir can be decreased when combined with 6-Deoxyerythronolide B.
7-ethyl-10-hydroxycamptothecin
The metabolism of Famciclovir can be decreased when combined with 7-ethyl-10-hydroxycamptothecin.
9-aminocamptothecin
The metabolism of 9-aminocamptothecin can be decreased when combined with Famciclovir.
Abatacept
The metabolism of Famciclovir can be increased when combined with Abatacept.
Acalabrutinib
The metabolism of Famciclovir can be decreased when combined with Acalabrutinib.
Acenocoumarol
The metabolism of Acenocoumarol can be decreased when combined with Famciclovir.
Acetaminophen
The metabolism of Famciclovir can be increased when combined with Acetaminophen.
Acetazolamide
The metabolism of Famciclovir can be decreased when combined with Acetazolamide.
Adalimumab
The metabolism of Famciclovir can be increased when combined with Adalimumab.
Adenovirus type 7 vaccine live
The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Famciclovir.
Afelimomab
The metabolism of Famciclovir can be increased when combined with Afelimomab.
Albendazole
The metabolism of Albendazole can be decreased when combined with Famciclovir.
Aldesleukin
The metabolism of Famciclovir can be decreased when combined with Aldesleukin.
Alfentanil
The metabolism of Alfentanil can be decreased when combined with Famciclovir.
Allylestrenol
The metabolism of Allylestrenol can be decreased when combined with Famciclovir.
Alpelisib
The metabolism of Famciclovir can be increased when combined with Alpelisib.
Alprazolam
The metabolism of Alprazolam can be decreased when combined with Famciclovir.
Aminoglutethimide
The metabolism of Famciclovir can be increased when combined with Aminoglutethimide.
Aminophylline
The metabolism of Aminophylline can be decreased when combined with Famciclovir.