Description

Simple

An antibiotic related to penicillin that is used to treat a wide variety of infections in the body caused by bacteria.

Clinical

A penicillin derivative used for the treatment of a variety of infections caused by gram-positive and gram-negative bacteria as well as some anaerobes.

Overview

Ampicillin is a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.

Pharmacology

Indication

For treatment of infection (Respiratory, GI, UTI and meningitis) due to E. coli, P. mirabilis, enterococci, Shigella, S. typhosa and other Salmonella, nonpenicillinase-producing N. gononhoeae, H. influenzae, staphylococci, streptococci including streptoc

Pharmacodynamic

Ampicillin is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Am... Read more

Mechanism of action

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, Ampicillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Ampicillin int... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Ampicillin is excreted largely unchanged in the urine.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

  • Hypersensitivity:
    • true
  • Regions: US

Food Interactions

  • Take on an empty stomach.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
Ampicillin may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Ampicillin may increase the anticoagulant activities of (S)-Warfarin.
4-hydroxycoumarin
Ampicillin may increase the anticoagulant activities of 4-hydroxycoumarin.
Abacavir
Ampicillin may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acarbose
Acarbose may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Aceclofenac
Aceclofenac may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Acemetacin
Acemetacin may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Acenocoumarol
Ampicillin may increase the anticoagulant activities of Acenocoumarol.
Acetaminophen
Acetaminophen may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Acetazolamide
Acetazolamide may increase the excretion rate of Ampicillin which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acid
Acetylsalicylic acid may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Aclidinium
Ampicillin may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Ampicillin may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir
Acyclovir may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Adefovir
Adefovir may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Adefovir dipivoxil
Adefovir dipivoxil may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Albutrepenonacog alfa
Ampicillin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Alclofenac
Alclofenac may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Alcuronium
The therapeutic efficacy of Alcuronium can be increased when used in combination with Ampicillin.
Aldesleukin
Aldesleukin may decrease the excretion rate of Ampicillin which could result in a higher serum level.