Description

Simple

A medication used to treat allergy symptoms and trouble sleeping, and is combined with vitamins to treat nausea and vomiting during pregnancy.

Clinical

An antihistamine used to treat insomnia and allergy symptoms and is used with pyridoxine in the treatment of nausea and vomiting in pregnancy.

Overview

Histamine H1 antagonist with pronounced sedative properties. It is used in allergies and as an antitussive, antiemetic, and hypnotic. Doxylamine has also been administered in veterinary applications and was formerly used in parkinsonism.

Pharmacology

Indication

Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.

Pharmacodynamic

Doxylamine is an antihistamine commonly used as a sleep aid. This drug is also used to relieve symptoms of hay fever (allergic rhinitis), hives (rash or itching), and other allergic reactions. Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power far superior... Read more

Mechanism of action

Like other antihistamines, doxylamine acts by competitively inhibiting histamine at H1 receptors. It also has substantial sedative and anticholinergic effects.

Absorption

Readily absorbed via the gastrointestinal tract.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

10 hours

Route of elimination

Information currently not available.

Toxicity

Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Doxylamine
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
1,10-Phenanthroline
The therapeutic efficacy of Doxylamine can be decreased when used in combination with 1,10-Phenanthroline.
2,5-Dimethoxy-4-ethylamphetamine
2,5-Dimethoxy-4-ethylamphetamine may decrease the sedative and stimulatory activities of Doxylamine.
2,5-Dimethoxy-4-ethylthioamphetamine
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of 2,5-Dimethoxy-4-ethylthioamphetamine.
4-Bromo-2,5-dimethoxyamphetamine
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of 4-Bromo-2,5-dimethoxyamphetamine.
4-Methoxyamphetamine
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of 5-methoxy-N,N-dimethyltryptamine.
7-Nitroindazole
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of 7-Nitroindazole.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Abediterol
The risk or severity of Tachycardia can be increased when Doxylamine is combined with Abediterol.
Abexinostat
The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Abexinostat.
Acebutolol
The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Acebutolol.
Acepromazine
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Acepromazine.
Aceprometazine
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Aceprometazine.
Acetazolamide
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Acetazolamide.
Acetophenazine
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Acetophenazine.
Acetyldigoxin
The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Acetyldigoxin.
Acetylglycinamide chloral hydrate
Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Acetylglycinamide chloral hydrate.
Aclidinium
The risk or severity of adverse effects can be increased when Doxylamine is combined with Aclidinium.
Acotiamide
The therapeutic efficacy of Doxylamine can be decreased when used in combination with Acotiamide.
Acrivastine
The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Acrivastine.