Description

Simple

An antibiotic used with other medications to treat tuberculosis (TB).

Clinical

An aminoglycoside antibiotic used as an adjunct drug in tuberculosis.

Overview

Cyclic peptide antibiotic similar to viomycin. It is produced by Streptomyces capreolus.

Pharmacology

Indication

Used in the treatment of tuberculosis in combination with other drugs.

Pharmacodynamic

Capreomycin is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria, including bacteria responsible for causing tuberculosis (TB).

Mechanism of action

Little is known about capreomycin's exact mechanism of action, but it is thought to inhibit protein synthesis by binding to the 70S ribosomal unit. Capreomycin also binds to components in the bacterial cell which result in the production of abnormal proteins. These proteins are necessary for the bac... Read more

Absorption

Not absorbed in significant quantities from the gastrointestinal tract and must be administered parenterally.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

When a 1–g dose of capreomycin was given intramuscularly to normal volunteers, 52% was excreted in the urine within 12 hours.

Toxicity

Hypokalemia, hypocalcemia, hypomagnesemia, and an electrolyte disturbance resembling Bartter's syndrome have been reported to occur in patients with capreomycin toxicity. The subcutaneous median lethal dose (LD50) in mice was 514 mg/kg.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The risk or severity of bleeding can be increased when Capreomycin is combined with (R)-warfarin.
(S)-Warfarin
The risk or severity of bleeding can be increased when Capreomycin is combined with (S)-Warfarin.
4-hydroxycoumarin
The risk or severity of bleeding can be increased when Capreomycin is combined with 4-hydroxycoumarin.
Abacavir
Abacavir may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Acarbose
Acarbose may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Aceclofenac
Aceclofenac may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Acemetacin
Acemetacin may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Acenocoumarol
The risk or severity of bleeding can be increased when Capreomycin is combined with Acenocoumarol.
Acetaminophen
Acetaminophen may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Acetazolamide
Acetazolamide may increase the excretion rate of Capreomycin which could result in a lower serum level and potentially a reduction in efficacy.
Acetylcholine
The therapeutic efficacy of Acetylcholine can be decreased when used in combination with Capreomycin.
Acetyldigitoxin
The risk or severity of adverse effects can be increased when Capreomycin is combined with Acetyldigitoxin.
Acetyldigoxin
The risk or severity of adverse effects can be increased when Capreomycin is combined with Acetyldigoxin.
Acetylsalicylic acid
Acetylsalicylic acid may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Aclidinium
Aclidinium may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Acrivastine
Acrivastine may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Acyclovir
Acyclovir may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Adefovir
Adefovir may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Adefovir dipivoxil
Adefovir dipivoxil may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Albutrepenonacog alfa
Albutrepenonacog alfa may decrease the excretion rate of Capreomycin which could result in a higher serum level.