Description

Simple

A medication used in kidney failure that lowers the level of phosphate, a mineral in the body that can cause calcium to settle in various parts of the body when levels are too high.

Clinical

A phosphate binder used in patients with end-stage renal disease (ESRD) to prevent elevated phosphate levels and resulting ectopic calcification and secondary hyperparathyroidism.

Overview

The chemical compound calcium acetate is the calcium salt of acetic acid. It has been commonly referred to as the acetate of lime. The anhydrous form is very hygroscopic, therefore the monohydrate is the common form.

Pharmacology

Indication

Calcium acetate is one of a number of calcium salts used to treat hyperphosphatemia (too much phosphate in the blood) in patients with kidney disease.

Pharmacodynamic

Patients with advanced renal insufficiency (creatinine clearance less than 30 ml/min) exhibit phosphate retention and some degree of hyperphosphatemia. The retention of phosphate plays a pivotal role in causing secondary hyperparathyroidism associated with osteodystrophy, and soft-tissue calcificati... Read more

Mechanism of action

Calcium acetate and other calcium salts are phosphate binders. They work by binding with the phosphate in the food you eat, so that it is eliminated from the body without being absorbed.

Absorption

40% is absorbed in the fasting state and approximately 30% is absorbed in the nonfasting state following oral administration.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Calcium acetate when taken with meals, combines with dietary phosphate to form insoluble calcium phosphate which is excreted in the feces.

Toxicity

Oral, rat: LD50 = 4280 mg/kg. Symptoms of overdose include mild hypercalcemia (constipation; loss of appetite; nausea and vomiting), and severe hypercalcemia (confusion; full or partial loss of consciousness; incoherent speech).

Adverse Effects

Contraindications

  • Regions: US
  • Patient Conditions:
      • Name: Hypercalcemia
      • Drugbank Id: DBCOND0003950
  • Hypersensitivity:
    • false
  • Regions: US

Food Interactions

  • Take with food. When taken with food, calcium acetate forms an insoluble complex with the phosphorus from food, reducing phosphorus serum concentrations.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
(R)-warfarin
The therapeutic efficacy of Calcium acetate can be decreased when used in combination with (R)-warfarin.
(S)-Warfarin
The therapeutic efficacy of Calcium acetate can be decreased when used in combination with (S)-Warfarin.
1alpha-Hydroxyvitamin D5
The risk or severity of adverse effects can be increased when Calcium acetate is combined with 1alpha-Hydroxyvitamin D5.
1alpha,24S-Dihydroxyvitamin D2
The risk or severity of adverse effects can be increased when Calcium acetate is combined with 1alpha,24S-Dihydroxyvitamin D2.
3-Aza-2,3-Dihydrogeranyl Diphosphate
Calcium acetate can cause a decrease in the absorption of 3-Aza-2,3-Dihydrogeranyl Diphosphate resulting in a reduced serum concentration and potentially a decrease in efficacy.
4-hydroxycoumarin
The therapeutic efficacy of Calcium acetate can be decreased when used in combination with 4-hydroxycoumarin.
Abciximab
The therapeutic efficacy of Calcium acetate can be decreased when used in combination with Abciximab.
Acebutolol
The therapeutic efficacy of Acebutolol can be decreased when used in combination with Calcium acetate.
Acenocoumarol
The therapeutic efficacy of Calcium acetate can be decreased when used in combination with Acenocoumarol.
Acetyldigitoxin
Calcium acetate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Acetyldigoxin
Calcium acetate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigoxin.
Acetylsalicylic acid
The therapeutic efficacy of Calcium acetate can be decreased when used in combination with Acetylsalicylic acid.
Agmatine
The therapeutic efficacy of Agmatine can be decreased when used in combination with Calcium acetate.
Alendronic acid
The serum concentration of Alendronic acid can be decreased when it is combined with Calcium acetate.
Alfacalcidol
The risk or severity of adverse effects can be increased when Calcium acetate is combined with Alfacalcidol.
Alpha-1-proteinase inhibitor
Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Calcium acetate.
Alprenolol
The therapeutic efficacy of Alprenolol can be decreased when used in combination with Calcium acetate.
Alteplase
The therapeutic efficacy of Calcium acetate can be decreased when used in combination with Alteplase.
Amediplase
The therapeutic efficacy of Calcium acetate can be decreased when used in combination with Amediplase.
Aminocaproic acid
The risk or severity of adverse effects can be increased when Aminocaproic acid is combined with Calcium acetate.