Description

Simple

An injection that helps to diagnose problems during a magnetic resonance imaging (MRI) scan by allowing abnormal tissues to be seen more clearly.

Clinical

A gadolinium-based contrast agent used for the visualization of lesions with vascularity during magnetic resonance imaging (MRI) scans.

Overview

Gadodiamide is a paramagnetic gadolinium-based contrast agent (GBCA) that is used in MR imaging procedures to assist in the visualization of blood vessels. It is intravenously injected and is commonly marketed under the trade name Omniscan.

Pharmacology

Indication

For intravenous use in MRI to visualize lesions with abnormal vascularity (or those thought to cause abnormalities in the blood-brain barrier) in the brain (intracranial lesions), spine, and associated tissues.

Pharmacodynamic

Information currently not available.

Mechanism of action

Based on the behavior of protons when placed in a strong magnetic field, which is interpreted and transformed into images by magnetic resonance (MR) instruments. Paramagnetic agents have unpaired electrons that generate a magnetic field about 700 times larger than the proton's field, thus disturbing... Read more

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

200 ± 61 mL/kg

Clearance

Renal cl=1.7 mL/min/kgPlasma cl=1.8 mL/min/kg

Half life

Two-compartment model with mean distribution and elimination half-lives (reported as mean ± SD) of 3.7 ± 2.7 minutes and 77.8 ± 16 minutes, respectively.

Route of elimination

Gadodiamide is eliminated primarily in the urine.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

  • Regions: US
  • Patient Conditions:
      • Name: Chronic severe kidney disease
      • Drugbank Id: DBCOND0107506
      • Modification Of:
        • Base:
          • Name: Kidney Disease
          • Drugbank Id: DBCOND0027958
        • Severity:
          • Includes:
            • chronic
            • severe
  • Regions: US
  • Patient Conditions:
      • Name: Acute Kidney Injury
      • Drugbank Id: DBCOND0032980
      • Modification Of:
        • Base:
          • Name: Kidney Injury
          • Drugbank Id: DBCOND0039679
        • Severity:
          • Includes:
            • acute

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
Abacavir
Gadodiamide may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acarbose
Gadodiamide may decrease the excretion rate of Acarbose which could result in a higher serum level.
Aceclofenac
Aceclofenac may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
Acemetacin
Acemetacin may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
Acetaminophen
Gadodiamide may decrease the excretion rate of Acetaminophen which could result in a higher serum level.
Acetazolamide
Acetazolamide may increase the excretion rate of Gadodiamide which could result in a lower serum level and potentially a reduction in efficacy.
Acetylsalicylic acid
Acetylsalicylic acid may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
Aclidinium
Gadodiamide may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Gadodiamide may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Acyclovir
Acyclovir may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
Adefovir
Adefovir may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
Adefovir dipivoxil
Adefovir dipivoxil may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
Albutrepenonacog alfa
Gadodiamide may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Alclofenac
Alclofenac may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
Aldesleukin
Aldesleukin may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
Allopurinol
Gadodiamide may decrease the excretion rate of Allopurinol which could result in a higher serum level.
Allylestrenol
Gadodiamide may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
Almasilate
Gadodiamide may decrease the excretion rate of Almasilate which could result in a higher serum level.
Alminoprofen
Alminoprofen may decrease the excretion rate of Gadodiamide which could result in a higher serum level.
Almotriptan
Gadodiamide may decrease the excretion rate of Almotriptan which could result in a higher serum level.