Description

Simple

A medication similar to vitamin D that is used to treat hyperparathyroidism, a hormonal disorder, as well as to give nutrition to patients on dialysis.

Clinical

An active metabolite of vitamin D used to treat hyperparathyroidism as well as to combat hypocalcemia in dialysis patients.

Overview

The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.

Pharmacology

Indication

Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction... Read more

Pharmacodynamic

Calcidiol is the precursor of vitamin D3. Vitamin D3 is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, in mineralization of bone, and for the assimilation of vitamin A. The classical manifestations of vitamin D deficiency is ric... Read more

Mechanism of action

Calcidiol is transformed in the kidney by 25-hydroxyvitamin D3-1-(alpha)-hydroxylase to calcitriol, the active form of vitamin D3. Calcitriol binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and th... Read more

Absorption

Readily absorbed.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

288 hours

Route of elimination

Information currently not available.

Toxicity

Bone pain, constipation (especially in children or adolescents), diarrhea, drowsiness, dryness of mouth; headache (continuing), increased thirst, increase in frequency of urination, especially at night, or in amount of urine, irregular heartbeat, itching skin, loss of appetite, metallic taste, muscl... Read more

Adverse Effects

Contraindications

  • Hypersensitivity:
    • false
  • Regions: US
  • Patient Conditions:
      • Name: None
      • Drugbank Id: DBCOND0107411

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Calcifediol
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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
1alpha-Hydroxyvitamin D5
The risk or severity of adverse effects can be increased when Calcifediol is combined with 1alpha-Hydroxyvitamin D5.
1alpha,24S-Dihydroxyvitamin D2
The risk or severity of adverse effects can be increased when Calcifediol is combined with 1alpha,24S-Dihydroxyvitamin D2.
Acetyldigitoxin
The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Calcifediol is combined with Acetyldigitoxin.
Acetyldigoxin
The risk or severity of ventricular arrhythmias and Cardiac Arrhythmia can be increased when Calcifediol is combined with Acetyldigoxin.
Aldosterone
The therapeutic efficacy of Calcifediol can be decreased when used in combination with Aldosterone.
Alfacalcidol
The risk or severity of adverse effects can be increased when Calcifediol is combined with Alfacalcidol.
Aluminum hydroxide
The serum concentration of Aluminum hydroxide can be increased when it is combined with Calcifediol.
Beclomethasone dipropionate
The therapeutic efficacy of Calcifediol can be decreased when used in combination with Beclomethasone dipropionate.
Becocalcidiol
The risk or severity of adverse effects can be increased when Calcifediol is combined with Becocalcidiol.
Bendroflumethiazide
The risk or severity of hypercalcemia can be increased when Bendroflumethiazide is combined with Calcifediol.
Benzthiazide
The risk or severity of hypercalcemia can be increased when Benzthiazide is combined with Calcifediol.
Betamethasone
The therapeutic efficacy of Calcifediol can be decreased when used in combination with Betamethasone.
Betamethasone phosphate
The therapeutic efficacy of Calcifediol can be decreased when used in combination with Betamethasone phosphate.
Budesonide
The therapeutic efficacy of Calcifediol can be decreased when used in combination with Budesonide.
Calcitriol
The risk or severity of adverse effects can be increased when Calcitriol is combined with Calcifediol.
Calcium
The risk or severity of adverse effects can be increased when Calcium is combined with Calcifediol.
Calcium acetate
The risk or severity of adverse effects can be increased when Calcium acetate is combined with Calcifediol.
Calcium carbonate
The risk or severity of adverse effects can be increased when Calcium carbonate is combined with Calcifediol.
Calcium cation
The risk or severity of adverse effects can be increased when Calcium cation is combined with Calcifediol.
Calcium chloride
The risk or severity of adverse effects can be increased when Calcium chloride is combined with Calcifediol.