Description

Simple

A nutrient commonly found in a wide variety of multivitamins.

Clinical

A vitamin used to correct vitamin C deficiency and to increase the intestinal absorption of iron.

Overview

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Pharmacology

Indication

Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent.

Pharmacodynamic

Ascorbic Acid (vitamin C) is a water-soluble vitamin indicated for the prevention and treatment of scurvy, as ascorbic acid deficiency results in scurvy. Collagenous structures are primarily affected, and lesions develop in bones and blood vessels. Administration of ascorbic acid completely reverses... Read more

Mechanism of action

In humans, an exogenous source of ascorbic acid is required for collagen formation and tissue repair by acting as a cofactor in the posttranslational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Ascorbic acid is reversibly oxidized to dehydroascorbic acid... Read more

Absorption

70% to 90%

Protein binding

25%

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

16 days (3.4 hours in people who have excess levels of vitamin C)

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

Type in a drug name to check for interaction with Ascorbic acid
Type a drug name in the box above to get started
  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
2,5-Dimethoxy-4-ethylamphetamine
The serum concentration of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when it is combined with Ascorbic acid.
2,5-Dimethoxy-4-ethylthioamphetamine
The serum concentration of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when it is combined with Ascorbic acid.
4-Bromo-2,5-dimethoxyamphetamine
The serum concentration of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when it is combined with Ascorbic acid.
Abemaciclib
The serum concentration of Ascorbic acid can be increased when it is combined with Abemaciclib.
Acebutolol
The serum concentration of Acebutolol can be increased when it is combined with Ascorbic acid.
Acetylsalicylic acid
The serum concentration of Acetylsalicylic acid can be increased when it is combined with Ascorbic acid.
Afatinib
The serum concentration of Ascorbic acid can be increased when it is combined with Afatinib.
Albendazole
The serum concentration of Ascorbic acid can be increased when it is combined with Albendazole.
Aldosterone
The serum concentration of Aldosterone can be increased when it is combined with Ascorbic acid.
Alectinib
The serum concentration of Ascorbic acid can be increased when it is combined with Alectinib.
Alfentanil
The serum concentration of Ascorbic acid can be increased when it is combined with Alfentanil.
Alitretinoin
The serum concentration of Alitretinoin can be increased when it is combined with Ascorbic acid.
Alpelisib
The serum concentration of Ascorbic acid can be increased when it is combined with Alpelisib.
Aluminum hydroxide
Ascorbic acid can cause an increase in the absorption of Aluminum hydroxide resulting in an increased serum concentration and potentially a worsening of adverse effects.
Ambrisentan
The serum concentration of Ambrisentan can be increased when it is combined with Ascorbic acid.
Amiodarone
The serum concentration of Ascorbic acid can be increased when it is combined with Amiodarone.
Amitriptyline
The serum concentration of Amitriptyline can be increased when it is combined with Ascorbic acid.
Amlodipine
The serum concentration of Ascorbic acid can be increased when it is combined with Amlodipine.
Amodiaquine
The serum concentration of Ascorbic acid can be increased when it is combined with Amodiaquine.
Amoxapine
The serum concentration of Ascorbic acid can be increased when it is combined with Amoxapine.
6 References
  1. 1 . Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M: Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35.PubMed: 12569111
  2. 2 . Meister A: Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem. 1994 Apr 1;269(13):9397-400.PubMed: 8144521
  3. 3 . Englard S, Seifter S: The biochemical functions of ascorbic acid. Annu Rev Nutr. 1986;6:365-406.PubMed: 3015170
  4. 4 . Banhegyi G, Mandl J: The hepatic glycogenoreticular system. Pathol Oncol Res. 2001;7(2):107-10.PubMed: 11458272
  5. 5 . Proctor P: Similar functions of uric acid and ascorbate in man? Nature. 1970 Nov 28;228(5274):868.PubMed: 5477017
  6. 6 . Korcok J, Dixon SJ, Lo TC, Wilson JX: Differential effects of glucose on dehydroascorbic acid transport and intracellular ascorbate accumulation in astrocytes and skeletal myocytes. Brain Res. 2003 Dec 12;993(1-2):201-7.PubMed: 14642847