Description

Simple

Clinical

Overview

A synthetic nonapeptide comprising cysteinyl, phenylalanyl, phenylalanyl, glutaminyl, asparaginyl, cysteinyl, prolyl, lysyl, and glycinamide residues in sequence, with a disulfide bridge joining the two cysteine residues. Its antidiuretic effects are less than those of vasopressin. It is a non-catecholamine vasoconstrictor used in local anaesthetic injections for dental use, and is an ingredient of preparations that have been used for treatment of pain and inflammation of the mouth.

Pharmacology

Indication

For use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential.

Pharmacodynamic

Felypressin is a synthetic analog of lypressin or vasopressin with a greater vasoconstrictor activity than antidiuretic action. It is used primarily as a hemostatic.

Mechanism of action

Felypressin binds to the vasopressin receptor V1a. This causes contraction of the smooth muscle in the vascular bed, especially capillaries, small arterioles and venules.

Absorption

Information currently not available.

Protein binding

Information currently not available.

Volume of distribution

Information currently not available.

Clearance

Information currently not available.

Half life

Information currently not available.

Route of elimination

Information currently not available.

Toxicity

Information currently not available.

Adverse Effects

Contraindications

Information currently not available.

Food Interactions

    Information currently not available.

Interactions

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  • Paracetamol(acetaminophen)
  • Paxil(paroxetine)
  • Pamelor(nortriptyline)
  • Panadol(acetaminophen)
  • Patanol(olopatadine ophthalmic)
  • Pataday(olopatadine ophthalmic)
  • Parnate(tranylcypromine)
  • Pazeo(olopatadine ophthalmic)
Levothyroxine
Levothyroxine may increase the vasoconstricting activities of Felypressin.
Lidocaine
The risk or severity of hypertension can be increased when Felypressin is combined with Lidocaine.
Liothyronine
Liothyronine may increase the vasoconstricting activities of Felypressin.
Liotrix
Liotrix may increase the vasoconstricting activities of Felypressin.
Patent Blue
The risk or severity of hypotension can be increased when Patent Blue is combined with Felypressin.
Thyroid, porcine
Thyroid, porcine may increase the vasoconstricting activities of Felypressin.
Thyrotropin alfa
Thyrotropin alfa may increase the vasoconstricting activities of Felypressin.
Tiratricol
Tiratricol may increase the vasoconstricting activities of Felypressin.
1 References
  1. 1 . Cecanho R, De Luca LA Jr, Ranali J: Cardiovascular effects of felypressin. Anesth Prog. 2006 Winter;53(4):119-25.PubMed: 17177590